Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation
Objective: to study systemic hemodynamic changes, by taking into account the typological features of a blood circulatory device in anemic animals when therapeutic measures were implemented.Materials and methods. Experiments were made on 58 dogs in 3 series of experiments: 1) 20 animals under hemorrh...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-04-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1052 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341187632136192 |
|---|---|
| author | Yu. M. Tumanovsky G. Yu. Savina |
| author_facet | Yu. M. Tumanovsky G. Yu. Savina |
| author_sort | Yu. M. Tumanovsky |
| collection | DOAJ |
| description | Objective: to study systemic hemodynamic changes, by taking into account the typological features of a blood circulatory device in anemic animals when therapeutic measures were implemented.Materials and methods. Experiments were made on 58 dogs in 3 series of experiments: 1) 20 animals under hemorrhagic shock (a control group); 2) 18 anemic animals receiving further infusion therapy; and 3) 20 anemic animals exposed to hyperbaric oxygenation (HBO) (pO2 = 300 kPa; 60-min session). In each series, animals with eukinetic, hypokinetic, and hyperkinetic circulations were identified. Cardiac and stroke indices (CI and SI), left ventricular stroke output index (LVSOI), specific peripheral vascular resistance (SPVR), double product (DP), heart rate, and blood pressure (BP) were determined at the baseline, at 30- and 90-minute shock and after treatment.Results. In the late posthemorrhagic period (at min 90), the preferential preponderance of hyperkinetic circulation in untreated animals in the late stage was characterized by the exhaustion of cardiovascular compensatory reactions and attended by a reduction in BP and central hemodynamic parameters (CI, SI, LVSOI) and evolving tachycardia. In the animals with all typological groups, infusion therapy produced a short-term impact on the activation of compensatory hemodynamic reactions, by increasing vascular tone with relatively low baseline central hemodynamic values, which was due to the fact that the heart was overloaded with the excess volume of an infusion mixture and myocardial contractility was diminished. Under HBO, recovery of the baseline ratio of circulatory types increased cardiac functional reserves and eliminated myocardial hypoxia (DP normalization).Conclusion. In hypoxia, recovery of hemodynamic homeostasis in anemic animals is determined by the optimization of adaptive functional mechanisms responsible for circulatory regulation. |
| format | Article |
| id | doaj-art-1df0ffff657a452b8eabd51685bc85a8 |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-1df0ffff657a452b8eabd51685bc85a82025-08-20T03:43:41ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-04-01325810.15360/1813-9779-2007-2-5-81052Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric OxygenationYu. M. Tumanovsky0G. Yu. Savina1N. N. Burdenko Voronezh State Medical AcademyN. N. Burdenko Voronezh State Medical AcademyObjective: to study systemic hemodynamic changes, by taking into account the typological features of a blood circulatory device in anemic animals when therapeutic measures were implemented.Materials and methods. Experiments were made on 58 dogs in 3 series of experiments: 1) 20 animals under hemorrhagic shock (a control group); 2) 18 anemic animals receiving further infusion therapy; and 3) 20 anemic animals exposed to hyperbaric oxygenation (HBO) (pO2 = 300 kPa; 60-min session). In each series, animals with eukinetic, hypokinetic, and hyperkinetic circulations were identified. Cardiac and stroke indices (CI and SI), left ventricular stroke output index (LVSOI), specific peripheral vascular resistance (SPVR), double product (DP), heart rate, and blood pressure (BP) were determined at the baseline, at 30- and 90-minute shock and after treatment.Results. In the late posthemorrhagic period (at min 90), the preferential preponderance of hyperkinetic circulation in untreated animals in the late stage was characterized by the exhaustion of cardiovascular compensatory reactions and attended by a reduction in BP and central hemodynamic parameters (CI, SI, LVSOI) and evolving tachycardia. In the animals with all typological groups, infusion therapy produced a short-term impact on the activation of compensatory hemodynamic reactions, by increasing vascular tone with relatively low baseline central hemodynamic values, which was due to the fact that the heart was overloaded with the excess volume of an infusion mixture and myocardial contractility was diminished. Under HBO, recovery of the baseline ratio of circulatory types increased cardiac functional reserves and eliminated myocardial hypoxia (DP normalization).Conclusion. In hypoxia, recovery of hemodynamic homeostasis in anemic animals is determined by the optimization of adaptive functional mechanisms responsible for circulatory regulation.https://www.reanimatology.com/rmt/article/view/1052acute hemorrhagecirculatory typesadaptationinfusion therapyhyperbaric oxygenation |
| spellingShingle | Yu. M. Tumanovsky G. Yu. Savina Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation Общая реаниматология acute hemorrhage circulatory types adaptation infusion therapy hyperbaric oxygenation |
| title | Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation |
| title_full | Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation |
| title_fullStr | Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation |
| title_full_unstemmed | Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation |
| title_short | Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation |
| title_sort | typological features of circulation in anemic animals during infusion therapy and hyperbaric oxygenation |
| topic | acute hemorrhage circulatory types adaptation infusion therapy hyperbaric oxygenation |
| url | https://www.reanimatology.com/rmt/article/view/1052 |
| work_keys_str_mv | AT yumtumanovsky typologicalfeaturesofcirculationinanemicanimalsduringinfusiontherapyandhyperbaricoxygenation AT gyusavina typologicalfeaturesofcirculationinanemicanimalsduringinfusiontherapyandhyperbaricoxygenation |