A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling.
The ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assess...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0075717 |
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| author | Patrick W Hales Kim P Phipps Ramneek Kaur Christopher A Clark |
| author_facet | Patrick W Hales Kim P Phipps Ramneek Kaur Christopher A Clark |
| author_sort | Patrick W Hales |
| collection | DOAJ |
| description | The ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assessment of perfusion. Although kinetic models have been developed to describe perfusion in healthy tissue, the dynamic behaviour of the ASL signal in the brain tumor environment has not been extensively studied. We show here that dynamic ASL data acquired in brain tumors displays an increased level of 'biphasic' behaviour, compared to that seen in healthy tissue. A new two-stage model is presented which more accurately describes this behaviour, and provides measurements of perfusion, pre-capillary blood volume fraction and transit time, and capillary bolus arrival time. These biomarkers offer a novel contrast in the tumor and surrounding tissue, and provide a means for measuring tumor perfusion and vascular structural abnormalities in a fully non-invasive manner. |
| format | Article |
| id | doaj-art-1df08e5ceafb4fa69aa6f653f1c391c9 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-1df08e5ceafb4fa69aa6f653f1c391c92025-08-20T03:46:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7571710.1371/journal.pone.0075717A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling.Patrick W HalesKim P PhippsRamneek KaurChristopher A ClarkThe ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assessment of perfusion. Although kinetic models have been developed to describe perfusion in healthy tissue, the dynamic behaviour of the ASL signal in the brain tumor environment has not been extensively studied. We show here that dynamic ASL data acquired in brain tumors displays an increased level of 'biphasic' behaviour, compared to that seen in healthy tissue. A new two-stage model is presented which more accurately describes this behaviour, and provides measurements of perfusion, pre-capillary blood volume fraction and transit time, and capillary bolus arrival time. These biomarkers offer a novel contrast in the tumor and surrounding tissue, and provide a means for measuring tumor perfusion and vascular structural abnormalities in a fully non-invasive manner.https://doi.org/10.1371/journal.pone.0075717 |
| spellingShingle | Patrick W Hales Kim P Phipps Ramneek Kaur Christopher A Clark A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. PLoS ONE |
| title | A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. |
| title_full | A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. |
| title_fullStr | A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. |
| title_full_unstemmed | A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. |
| title_short | A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. |
| title_sort | two stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling |
| url | https://doi.org/10.1371/journal.pone.0075717 |
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