Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila
Summary: Mating status often modulates responses to courtship sounds in animals. The neural mechanisms underlying this modulation, however, have not been well clarified. Here, we show that dopaminergic signals are involved in modulating the responses of auditory sensory neurons in Drosophila melanog...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225014932 |
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| author | Haruna Yamakoshi Mihoko Horigome Shotaro Yamamoto Shoya Iwanami Shingo Iwami Ryoya Tanaka Yuki Ishikawa Azusa Kamikouchi |
| author_facet | Haruna Yamakoshi Mihoko Horigome Shotaro Yamamoto Shoya Iwanami Shingo Iwami Ryoya Tanaka Yuki Ishikawa Azusa Kamikouchi |
| author_sort | Haruna Yamakoshi |
| collection | DOAJ |
| description | Summary: Mating status often modulates responses to courtship sounds in animals. The neural mechanisms underlying this modulation, however, have not been well clarified. Here, we show that dopaminergic signals are involved in modulating the responses of auditory sensory neurons in Drosophila melanogaster females depending on their mating status. These neurons abundantly express three types of dopamine receptors, with some having direct synaptic connections with dopaminergic neurons. Of these receptors, suppressing the expression of Dop1R2 reduces sound responses of auditory sensory neurons in unmated but not mated females. Moreover, the expression of Dop1R2 in auditory sensory neurons enhances the song response behavior of unmated females, manifested by copulation receptivity when exposed to songs. Our research suggests that dopaminergic modulation via Dop1R2 is involved in mating the state-dependent regulation of auditory sensory processing. |
| format | Article |
| id | doaj-art-1df009bdd2814c468e938992249c5945 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-1df009bdd2814c468e938992249c59452025-08-20T03:41:18ZengElsevieriScience2589-00422025-09-0128911323210.1016/j.isci.2025.113232Mating status-dependent dopaminergic modulation of auditory sensory neurons in DrosophilaHaruna Yamakoshi0Mihoko Horigome1Shotaro Yamamoto2Shoya Iwanami3Shingo Iwami4Ryoya Tanaka5Yuki Ishikawa6Azusa Kamikouchi7Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, JapanGraduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi 464-8602, Japan; Corresponding authorSummary: Mating status often modulates responses to courtship sounds in animals. The neural mechanisms underlying this modulation, however, have not been well clarified. Here, we show that dopaminergic signals are involved in modulating the responses of auditory sensory neurons in Drosophila melanogaster females depending on their mating status. These neurons abundantly express three types of dopamine receptors, with some having direct synaptic connections with dopaminergic neurons. Of these receptors, suppressing the expression of Dop1R2 reduces sound responses of auditory sensory neurons in unmated but not mated females. Moreover, the expression of Dop1R2 in auditory sensory neurons enhances the song response behavior of unmated females, manifested by copulation receptivity when exposed to songs. Our research suggests that dopaminergic modulation via Dop1R2 is involved in mating the state-dependent regulation of auditory sensory processing.http://www.sciencedirect.com/science/article/pii/S2589004225014932Natural sciencesBiological sciencesNeuroscienceBehavioral neuroscienceSensory neuroscience |
| spellingShingle | Haruna Yamakoshi Mihoko Horigome Shotaro Yamamoto Shoya Iwanami Shingo Iwami Ryoya Tanaka Yuki Ishikawa Azusa Kamikouchi Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila iScience Natural sciences Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| title | Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila |
| title_full | Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila |
| title_fullStr | Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila |
| title_full_unstemmed | Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila |
| title_short | Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila |
| title_sort | mating status dependent dopaminergic modulation of auditory sensory neurons in drosophila |
| topic | Natural sciences Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225014932 |
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