Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants
Abstract Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium is the gold standard in craniofacial surgeries, various polymeric biomaterials are being explored as alternatives. However, polymeric materials can be bioinert, hindering integration with surr...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80335-z |
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| author | D S Abdullah Al Maruf Jiongyu Ren Kai Cheng Hai Xin Will Lewin Edmund Pickering Hedi Verena Kruse David Leinkram Krishnan Parthasarathi Innes Wise Benjamin Filippi Stephen Beirne Cate Froggatt James Wykes Dale Howes Natalka Suchowerska Maria A. Woodruff Jeremy M. Crook David R. McKenzie Jonathan R. Clark |
| author_facet | D S Abdullah Al Maruf Jiongyu Ren Kai Cheng Hai Xin Will Lewin Edmund Pickering Hedi Verena Kruse David Leinkram Krishnan Parthasarathi Innes Wise Benjamin Filippi Stephen Beirne Cate Froggatt James Wykes Dale Howes Natalka Suchowerska Maria A. Woodruff Jeremy M. Crook David R. McKenzie Jonathan R. Clark |
| author_sort | D S Abdullah Al Maruf |
| collection | DOAJ |
| description | Abstract Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium is the gold standard in craniofacial surgeries, various polymeric biomaterials are being explored as alternatives. However, polymeric materials can be bioinert, hindering integration with surrounding tissues. In this investigation, plasma ion immersion implantation (PIII)-treated polyether ether ketone (PEEK) and polyether ketone (PEK) implants were assessed in a sheep maxilla and mandible model. Defects were filled with PIII-treated PEEK and PEK implants, produced through fused filament fabrication (FFF) and selective laser sintering (SLS), respectively. Positive controls were grade 23 titanium implants via selective laser melting, while untreated PEEK implants served as negative controls. Surface analyses using scanning electron microscopy and atomic force microscopy revealed favorable properties. Osseointegration was qualitatively and quantitatively assessed at 8-, 10-, and 12-weeks post-implantation, showing significantly improved outcomes for both PIII-treated PEEK and PEK implants compared to untreated controls. The study suggests PIII treatment enhances FFF-printed PEEK’s osseointegration, and PIII-treated SLS-printed PEK achieves comparable osseointegration to 3D printed titanium. These findings underscore surface modification strategies’ potential for polymeric biomaterials, offering insights into developing alternative implant materials for craniofacial surgeries, with enhanced biocompatibility and osseointegration capabilities for improved clinical outcomes. |
| format | Article |
| id | doaj-art-1deefcc5504e4b0e9d00e5339b4234a5 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1deefcc5504e4b0e9d00e5339b4234a52025-08-20T03:07:41ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-80335-zEvaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implantsD S Abdullah Al Maruf0Jiongyu Ren1Kai Cheng2Hai Xin3Will Lewin4Edmund Pickering5Hedi Verena Kruse6David Leinkram7Krishnan Parthasarathi8Innes Wise9Benjamin Filippi10Stephen Beirne11Cate Froggatt12James Wykes13Dale Howes14Natalka Suchowerska15Maria A. Woodruff16Jeremy M. Crook17David R. McKenzie18Jonathan R. Clark19Central Clinical School, Faculty of Medicine and Health, The University of SydneySchool of Mechanical, Medical and Process Engineering, Queensland University of TechnologyRoyal Prince Alfred Institute of Academic Surgery, Sydney Local Health DistrictCentral Clinical School, Faculty of Medicine and Health, The University of SydneyArto Hardy Family Biomedical Innovation Hub, Chris O`Brien LifehouseSchool of Mechanical, Medical and Process Engineering, Queensland University of TechnologyArto Hardy Family Biomedical Innovation Hub, Chris O`Brien LifehouseIntegrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O’Brien LifehouseIntegrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O’Brien LifehouseLaboratory Animal Services, The University of SydneyAIIM Facility, Intelligent Polymer Research Institute, The University of WollongongAIIM Facility, Intelligent Polymer Research Institute, The University of WollongongIntegrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O’Brien LifehouseIntegrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O’Brien LifehouseIntegrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O’Brien LifehouseSchool of Physics, Faculty of Science, The University of SydneySchool of Mechanical, Medical and Process Engineering, Queensland University of TechnologyArto Hardy Family Biomedical Innovation Hub, Chris O`Brien LifehouseSchool of Physics, Faculty of Science, The University of SydneyCentral Clinical School, Faculty of Medicine and Health, The University of SydneyAbstract Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium is the gold standard in craniofacial surgeries, various polymeric biomaterials are being explored as alternatives. However, polymeric materials can be bioinert, hindering integration with surrounding tissues. In this investigation, plasma ion immersion implantation (PIII)-treated polyether ether ketone (PEEK) and polyether ketone (PEK) implants were assessed in a sheep maxilla and mandible model. Defects were filled with PIII-treated PEEK and PEK implants, produced through fused filament fabrication (FFF) and selective laser sintering (SLS), respectively. Positive controls were grade 23 titanium implants via selective laser melting, while untreated PEEK implants served as negative controls. Surface analyses using scanning electron microscopy and atomic force microscopy revealed favorable properties. Osseointegration was qualitatively and quantitatively assessed at 8-, 10-, and 12-weeks post-implantation, showing significantly improved outcomes for both PIII-treated PEEK and PEK implants compared to untreated controls. The study suggests PIII treatment enhances FFF-printed PEEK’s osseointegration, and PIII-treated SLS-printed PEK achieves comparable osseointegration to 3D printed titanium. These findings underscore surface modification strategies’ potential for polymeric biomaterials, offering insights into developing alternative implant materials for craniofacial surgeries, with enhanced biocompatibility and osseointegration capabilities for improved clinical outcomes.https://doi.org/10.1038/s41598-024-80335-zPlasma ion immersion implantationPolyether ether ketonePEEKPolyether ketonePEKMandible |
| spellingShingle | D S Abdullah Al Maruf Jiongyu Ren Kai Cheng Hai Xin Will Lewin Edmund Pickering Hedi Verena Kruse David Leinkram Krishnan Parthasarathi Innes Wise Benjamin Filippi Stephen Beirne Cate Froggatt James Wykes Dale Howes Natalka Suchowerska Maria A. Woodruff Jeremy M. Crook David R. McKenzie Jonathan R. Clark Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants Scientific Reports Plasma ion immersion implantation Polyether ether ketone PEEK Polyether ketone PEK Mandible |
| title | Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| title_full | Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| title_fullStr | Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| title_full_unstemmed | Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| title_short | Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| title_sort | evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants |
| topic | Plasma ion immersion implantation Polyether ether ketone PEEK Polyether ketone PEK Mandible |
| url | https://doi.org/10.1038/s41598-024-80335-z |
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