Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy
Hypocrellins (HYPs), naturally occurring 3,10-xylene-4,9-anthracene derivatives sourced from <i>Shiraia bambusicola</i> and <i>Hypocrella bambusae</i>, exhibit significant photobiological activities. Despite their capability for generating a high yield of reactive oxygen spec...
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MDPI AG
2024-10-01
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| Series: | Fermentation |
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| Online Access: | https://www.mdpi.com/2311-5637/10/11/559 |
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| author | Xiang Zhang Qiulin Wei Liwen Tian Zhixian Huang Yanbo Tang Yongdi Wen Fuqiang Yu Xiaoxiao Yan Yunchun Zhao Zhenqiang Wu Xiaofei Tian |
| author_facet | Xiang Zhang Qiulin Wei Liwen Tian Zhixian Huang Yanbo Tang Yongdi Wen Fuqiang Yu Xiaoxiao Yan Yunchun Zhao Zhenqiang Wu Xiaofei Tian |
| author_sort | Xiang Zhang |
| collection | DOAJ |
| description | Hypocrellins (HYPs), naturally occurring 3,10-xylene-4,9-anthracene derivatives sourced from <i>Shiraia bambusicola</i> and <i>Hypocrella bambusae</i>, exhibit significant photobiological activities. Despite their capability for generating a high yield of reactive oxygen species, including singlet oxygen and superoxide anion radical, their application in photodynamic therapy (PDT) is constrained. This limitation is due to their low dark phototoxicity, weak absorption within the therapeutic window of PDT (600–900 nm), and inherent hydrophobicity, which hinder their immediate use in amphipathic PDT applications. This review comprehensively discusses the research advancements in the bioactivities and biosynthesis of HYPs, alongside the reported chemical and physical modifications that enhance their water solubility and extend their therapeutic window. Additionally, it explores potential strategies for developing pharmaceuticals, photocatalytic agents, and photosensitive pesticides based on HYPs. |
| format | Article |
| id | doaj-art-1ded80edd7f04d8ebbe9caf5e29780e9 |
| institution | OA Journals |
| issn | 2311-5637 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fermentation |
| spelling | doaj-art-1ded80edd7f04d8ebbe9caf5e29780e92025-08-20T02:28:14ZengMDPI AGFermentation2311-56372024-10-01101155910.3390/fermentation10110559Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic TherapyXiang Zhang0Qiulin Wei1Liwen Tian2Zhixian Huang3Yanbo Tang4Yongdi Wen5Fuqiang Yu6Xiaoxiao Yan7Yunchun Zhao8Zhenqiang Wu9Xiaofei Tian10School of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023-1063 Shatai South Road, Guangzhou 510515, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaYunnan Key Laboratory for Fungal Diversity and Green Development, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650204, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, 382 East Out Loop, University Park, Guangzhou 510006, ChinaHypocrellins (HYPs), naturally occurring 3,10-xylene-4,9-anthracene derivatives sourced from <i>Shiraia bambusicola</i> and <i>Hypocrella bambusae</i>, exhibit significant photobiological activities. Despite their capability for generating a high yield of reactive oxygen species, including singlet oxygen and superoxide anion radical, their application in photodynamic therapy (PDT) is constrained. This limitation is due to their low dark phototoxicity, weak absorption within the therapeutic window of PDT (600–900 nm), and inherent hydrophobicity, which hinder their immediate use in amphipathic PDT applications. This review comprehensively discusses the research advancements in the bioactivities and biosynthesis of HYPs, alongside the reported chemical and physical modifications that enhance their water solubility and extend their therapeutic window. Additionally, it explores potential strategies for developing pharmaceuticals, photocatalytic agents, and photosensitive pesticides based on HYPs.https://www.mdpi.com/2311-5637/10/11/559fungal pesticidesphotobiological activityfermentationligand compounds |
| spellingShingle | Xiang Zhang Qiulin Wei Liwen Tian Zhixian Huang Yanbo Tang Yongdi Wen Fuqiang Yu Xiaoxiao Yan Yunchun Zhao Zhenqiang Wu Xiaofei Tian Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy Fermentation fungal pesticides photobiological activity fermentation ligand compounds |
| title | Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy |
| title_full | Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy |
| title_fullStr | Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy |
| title_full_unstemmed | Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy |
| title_short | Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy |
| title_sort | advancements and future prospects in hypocrellins production and modification for photodynamic therapy |
| topic | fungal pesticides photobiological activity fermentation ligand compounds |
| url | https://www.mdpi.com/2311-5637/10/11/559 |
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