Histone Lysine Methylation in Diabetic Nephropathy
Diabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide. Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes pat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/654148 |
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| author | Guang-dong Sun Wen-peng Cui Qiao-yan Guo Li-ning Miao |
| author_facet | Guang-dong Sun Wen-peng Cui Qiao-yan Guo Li-ning Miao |
| author_sort | Guang-dong Sun |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide. Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called “metabolic memory.” The underlying mechanisms responsible for the development and progression of DN remain poorly understood. Activation of multiple signaling pathways and key transcription factors can lead to aberrant expression of DN-related pathologic genes in target renal cells. Increasing evidence suggests that epigenetic mechanisms in chromatin such as DNA methylation, histone acetylation, and methylation can influence the pathophysiology of DN and metabolic memory. Exciting researches from cell culture and experimental animals have shown that key histone methylation patterns and the related histone methyltransferases and histone demethylases can play important roles in the regulation of inflammatory and profibrotic genes in renal cells under diabetic conditions. Because histone methylation is dynamic and potentially reversible, it can provide a window of opportunity for the development of much-needed novel therapeutic potential for DN in the future. In this minireview, we discuss recent advances in the field of histone methylation and its roles in the pathogenesis and progression of DN. |
| format | Article |
| id | doaj-art-1decba9bb55545a9a850ff91d0873d89 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1decba9bb55545a9a850ff91d0873d892025-08-20T02:01:40ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/654148654148Histone Lysine Methylation in Diabetic NephropathyGuang-dong Sun0Wen-peng Cui1Qiao-yan Guo2Li-ning Miao3Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDiabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide. Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called “metabolic memory.” The underlying mechanisms responsible for the development and progression of DN remain poorly understood. Activation of multiple signaling pathways and key transcription factors can lead to aberrant expression of DN-related pathologic genes in target renal cells. Increasing evidence suggests that epigenetic mechanisms in chromatin such as DNA methylation, histone acetylation, and methylation can influence the pathophysiology of DN and metabolic memory. Exciting researches from cell culture and experimental animals have shown that key histone methylation patterns and the related histone methyltransferases and histone demethylases can play important roles in the regulation of inflammatory and profibrotic genes in renal cells under diabetic conditions. Because histone methylation is dynamic and potentially reversible, it can provide a window of opportunity for the development of much-needed novel therapeutic potential for DN in the future. In this minireview, we discuss recent advances in the field of histone methylation and its roles in the pathogenesis and progression of DN.http://dx.doi.org/10.1155/2014/654148 |
| spellingShingle | Guang-dong Sun Wen-peng Cui Qiao-yan Guo Li-ning Miao Histone Lysine Methylation in Diabetic Nephropathy Journal of Diabetes Research |
| title | Histone Lysine Methylation in Diabetic Nephropathy |
| title_full | Histone Lysine Methylation in Diabetic Nephropathy |
| title_fullStr | Histone Lysine Methylation in Diabetic Nephropathy |
| title_full_unstemmed | Histone Lysine Methylation in Diabetic Nephropathy |
| title_short | Histone Lysine Methylation in Diabetic Nephropathy |
| title_sort | histone lysine methylation in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2014/654148 |
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