A high-throughput, fully automated competition assay to evaluate SARS-CoV-2 neutralizing responses and epitope specificity in clinical samples

A high-throughput, fully automated competition assay to evaluate SARS-CoV-2 neutralizing responses and epitope specificity in clinical samples

Abstract Coronavirus disease-2019 (COVID-19) remains a critical global health concern. We developed a fully automated, high-throughput competition immunoassay to elucidate how epitope recognition on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD)...

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Bibliographic Details
Main Authors: Yusuke Atarashi, Jeeeun Kim, Yasuhiro Irino, Masayuki Amano, Kiyoto Tsuchiya, Kenji Maeda, Mari Terada, Noriko Iwamoto, Shinya Shimada, Hiroaki Mitsuya, Masatoshi Yanagida, Yuki Takamatsu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
High throughput testing
Antibody test
Neutralizing activity
Online Access:https://doi.org/10.1038/s41598-025-94317-2
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