Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment
Odorant receptors (ORs) have long been thought to serve as chemosensors located on the cilia of olfactory sensory neurons (OSNs) in the olfactory epithelium, where they recognize odorant molecules and comprise the largest family of seven transmembrane-domain G protein-coupled receptors (GPCRs). Over...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/23/3938 |
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| author | Jingya Guo Seong-Gook Kang Kunlun Huang Tao Tong |
| author_facet | Jingya Guo Seong-Gook Kang Kunlun Huang Tao Tong |
| author_sort | Jingya Guo |
| collection | DOAJ |
| description | Odorant receptors (ORs) have long been thought to serve as chemosensors located on the cilia of olfactory sensory neurons (OSNs) in the olfactory epithelium, where they recognize odorant molecules and comprise the largest family of seven transmembrane-domain G protein-coupled receptors (GPCRs). Over the last three decades, accumulating evidence has suggested that ORs are distributed in a variety of peripheral tissues beyond their supposed typical tissue expression in the olfactory epithelium. These ectopic ORs play a role in regulating various cellular, physiological, and pathophysiological phenomena in the body, such as regulation of hypertension, hepatic glucose production, cancer development, and chronic skin disease. Adipose tissue, the key organ in regulating obesity and energy metabolism, has been reported to take advantage of ectopic OR-mediated signaling. In this review, we summarize and provide an in-depth analysis of the current research on the key biological functions of adipose tissue ORs in response to food-derived odorants, as well as the molecular mechanisms underlying their activity. |
| format | Article |
| id | doaj-art-1de9978e704e46aebeb3b94c04411fb5 |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-1de9978e704e46aebeb3b94c04411fb52025-08-20T02:38:47ZengMDPI AGFoods2304-81582024-12-011323393810.3390/foods13233938Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity TreatmentJingya Guo0Seong-Gook Kang1Kunlun Huang2Tao Tong3College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaDepartment of Food Engineering and Solar Salt Research Center, Mokpo National University, Muangun 58554, Republic of KoreaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaOdorant receptors (ORs) have long been thought to serve as chemosensors located on the cilia of olfactory sensory neurons (OSNs) in the olfactory epithelium, where they recognize odorant molecules and comprise the largest family of seven transmembrane-domain G protein-coupled receptors (GPCRs). Over the last three decades, accumulating evidence has suggested that ORs are distributed in a variety of peripheral tissues beyond their supposed typical tissue expression in the olfactory epithelium. These ectopic ORs play a role in regulating various cellular, physiological, and pathophysiological phenomena in the body, such as regulation of hypertension, hepatic glucose production, cancer development, and chronic skin disease. Adipose tissue, the key organ in regulating obesity and energy metabolism, has been reported to take advantage of ectopic OR-mediated signaling. In this review, we summarize and provide an in-depth analysis of the current research on the key biological functions of adipose tissue ORs in response to food-derived odorants, as well as the molecular mechanisms underlying their activity.https://www.mdpi.com/2304-8158/13/23/3938adipose tissueobesitycyclic adenosine monophosphateG protein-coupled receptorodorant receptorectopic function |
| spellingShingle | Jingya Guo Seong-Gook Kang Kunlun Huang Tao Tong Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment Foods adipose tissue obesity cyclic adenosine monophosphate G protein-coupled receptor odorant receptor ectopic function |
| title | Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment |
| title_full | Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment |
| title_fullStr | Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment |
| title_full_unstemmed | Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment |
| title_short | Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment |
| title_sort | targeting odorant receptors in adipose tissue with food derived odorants a novel approach to obesity treatment |
| topic | adipose tissue obesity cyclic adenosine monophosphate G protein-coupled receptor odorant receptor ectopic function |
| url | https://www.mdpi.com/2304-8158/13/23/3938 |
| work_keys_str_mv | AT jingyaguo targetingodorantreceptorsinadiposetissuewithfoodderivedodorantsanovelapproachtoobesitytreatment AT seonggookkang targetingodorantreceptorsinadiposetissuewithfoodderivedodorantsanovelapproachtoobesitytreatment AT kunlunhuang targetingodorantreceptorsinadiposetissuewithfoodderivedodorantsanovelapproachtoobesitytreatment AT taotong targetingodorantreceptorsinadiposetissuewithfoodderivedodorantsanovelapproachtoobesitytreatment |