A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus

A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus

Tripterygium wilfordii Hook F (TWHF) is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus (SLE), with triptolide (TP) as its main active ingredient. However, its side effects also induced by TP, especially hepatotoxicity and reproductive toxicity, largely li...

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Bibliographic Details
Main Authors: Lai Wang, Haoyuan Yin, Jiao Jiang, Qilin Li, Changxing Gao, Wenrui Li, Bo Zhang, Yue Xin, Hongyang Li, Ming Zhao, Qianjin Lu
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Systemic lupus erythematosus
Triptolide
CD19
Antibody‒drug conjugate
B cells
Reproductive toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002557
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