Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study
Abstract Purpose Evidence concerning the effect of cardiovascular health (CVH) on the risk of metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate the association between CVH and MASLD. Methods 5680 adults aged ≥ 20 years from the National Hea...
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BMC
2025-01-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-025-00745-1 |
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| author | Lian-Zhen Huang Ze-Bin Ni Wei-Feng Huang Li-Ping Sheng Yan-Qing Wang Jin-Yan Zhang |
| author_facet | Lian-Zhen Huang Ze-Bin Ni Wei-Feng Huang Li-Ping Sheng Yan-Qing Wang Jin-Yan Zhang |
| author_sort | Lian-Zhen Huang |
| collection | DOAJ |
| description | Abstract Purpose Evidence concerning the effect of cardiovascular health (CVH) on the risk of metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate the association between CVH and MASLD. Methods 5680 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey 2017-March 2020 were included. Life’s essential 8 (LE8) was applied to assess CVH. Weighted binary logistic regression was employed to calculate the odds ratio (OR) and 95% confidence interval (CI) to investigate the association of CVH with MASLD. Restricted cubic spline (RCS) was conducted to explore the dose-response association between LE8 and its subscales scores with MASLD. Results Among 5680 participants, 724, 3901, and 1055 had low, moderate, and high CVH levels, respectively, with a MASLD diagnosis prevalence of 36.83%. In the fully adjusted logistic regression model, ORs for MASLD were 0.50 (95% CI, 0.37–0.69) for participants with moderate CVH and 0.21 (95% CI, 0.13–0.34) for those with high CVH, when compared to those with low CVH (P < 0.001 for trend). OR for MASLD was 0.68 (95% CI, 0.61–0.77) for each 10-point increase in LE8 score. RCS model demonstrated a non-linear dose-response relationship between LE8 score and health factors score with MASLD, while a linear relationship was found between health behaviors score and MASLD. Subgroup analysis showed a consistent negative correlation between LE8 score and MASLD, and sensitivity analysis validated the reliability of these findings. Conclusions Higher LE8 score was associated with a lower risk of MASLD. Encouraging adherence to optimal CVH levels may help mitigate the burden of MASLD. |
| format | Article |
| id | doaj-art-1de77793f3ec46e99b9c9eda30d62a52 |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-1de77793f3ec46e99b9c9eda30d62a522025-01-19T12:27:55ZengBMCJournal of Health, Population and Nutrition2072-13152025-01-0144111210.1186/s41043-025-00745-1Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional studyLian-Zhen Huang0Ze-Bin Ni1Wei-Feng Huang2Li-Ping Sheng3Yan-Qing Wang4Jin-Yan Zhang5Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Ultrasound, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Purpose Evidence concerning the effect of cardiovascular health (CVH) on the risk of metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate the association between CVH and MASLD. Methods 5680 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey 2017-March 2020 were included. Life’s essential 8 (LE8) was applied to assess CVH. Weighted binary logistic regression was employed to calculate the odds ratio (OR) and 95% confidence interval (CI) to investigate the association of CVH with MASLD. Restricted cubic spline (RCS) was conducted to explore the dose-response association between LE8 and its subscales scores with MASLD. Results Among 5680 participants, 724, 3901, and 1055 had low, moderate, and high CVH levels, respectively, with a MASLD diagnosis prevalence of 36.83%. In the fully adjusted logistic regression model, ORs for MASLD were 0.50 (95% CI, 0.37–0.69) for participants with moderate CVH and 0.21 (95% CI, 0.13–0.34) for those with high CVH, when compared to those with low CVH (P < 0.001 for trend). OR for MASLD was 0.68 (95% CI, 0.61–0.77) for each 10-point increase in LE8 score. RCS model demonstrated a non-linear dose-response relationship between LE8 score and health factors score with MASLD, while a linear relationship was found between health behaviors score and MASLD. Subgroup analysis showed a consistent negative correlation between LE8 score and MASLD, and sensitivity analysis validated the reliability of these findings. Conclusions Higher LE8 score was associated with a lower risk of MASLD. Encouraging adherence to optimal CVH levels may help mitigate the burden of MASLD.https://doi.org/10.1186/s41043-025-00745-1Cardiovascular healthNHANESLife’s essential 8MASLD |
| spellingShingle | Lian-Zhen Huang Ze-Bin Ni Wei-Feng Huang Li-Ping Sheng Yan-Qing Wang Jin-Yan Zhang Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study Journal of Health, Population and Nutrition Cardiovascular health NHANES Life’s essential 8 MASLD |
| title | Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study |
| title_full | Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study |
| title_fullStr | Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study |
| title_full_unstemmed | Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study |
| title_short | Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study |
| title_sort | association between cardiovascular health and metabolic dysfunction associated steatotic liver disease a nationwide cross sectional study |
| topic | Cardiovascular health NHANES Life’s essential 8 MASLD |
| url | https://doi.org/10.1186/s41043-025-00745-1 |
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