Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine
We have studied methods for preparing biodegradable microparticles for regenerative medicine based on chitosan, polylactic acid, collagen and gelatin. The main methods of forming particles become emulsification, coacervation and gelation. These methods can achieve the necessary parameters of the pro...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2015-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/262 |
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| author | M. G. Gordienko T. N. Somov Y. S. Yusupova N. I. Chupikova N. V. Menshutina |
| author_facet | M. G. Gordienko T. N. Somov Y. S. Yusupova N. I. Chupikova N. V. Menshutina |
| author_sort | M. G. Gordienko |
| collection | DOAJ |
| description | We have studied methods for preparing biodegradable microparticles for regenerative medicine based on chitosan, polylactic acid, collagen and gelatin. The main methods of forming particles become emulsification, coacervation and gelation. These methods can achieve the necessary parameters of the product such as size, porosity and shape by varying process parameters such as temperature, stirring speed and the concentration of solutions. For drying the microparticles vacuum freeze drying was used, which allows to maintain the spherical shape of the particles after drying. The resulting microparticles were examined and photographed using a scanning electron microscope. To determine the cytotoxicity of the microparticles their cell growth and attachment were studied in vitro. |
| format | Article |
| id | doaj-art-1de4a4644fa044909fc71b91a5662019 |
| institution | Kabale University |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-1de4a4644fa044909fc71b91a56620192025-08-20T03:56:23ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752015-10-011056676256Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicineM. G. Gordienko0T. N. Somov1Y. S. Yusupova2N. I. Chupikova3N. V. Menshutina4Mendeleev University of Chemical Technology of Russia, Moscow, 125480Mendeleev University of Chemical Technology of Russia, Moscow, 125480Mendeleev University of Chemical Technology of Russia, Moscow, 125480LLC «Cellular Systems», Moscow, 125212Mendeleev University of Chemical Technology of Russia, Moscow, 125480We have studied methods for preparing biodegradable microparticles for regenerative medicine based on chitosan, polylactic acid, collagen and gelatin. The main methods of forming particles become emulsification, coacervation and gelation. These methods can achieve the necessary parameters of the product such as size, porosity and shape by varying process parameters such as temperature, stirring speed and the concentration of solutions. For drying the microparticles vacuum freeze drying was used, which allows to maintain the spherical shape of the particles after drying. The resulting microparticles were examined and photographed using a scanning electron microscope. To determine the cytotoxicity of the microparticles their cell growth and attachment were studied in vitro.https://www.finechem-mirea.ru/jour/article/view/262regenerative medicine, microparticles, biodegradability, gelatin, chitosan, polylactic acid. |
| spellingShingle | M. G. Gordienko T. N. Somov Y. S. Yusupova N. I. Chupikova N. V. Menshutina Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine Тонкие химические технологии regenerative medicine, microparticles, biodegradability, gelatin, chitosan, polylactic acid. |
| title | Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| title_full | Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| title_fullStr | Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| title_full_unstemmed | Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| title_short | Preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| title_sort | preparation of spherical microparticles from biodegradable natural and synthetic polymers for their application in regenerative medicine |
| topic | regenerative medicine, microparticles, biodegradability, gelatin, chitosan, polylactic acid. |
| url | https://www.finechem-mirea.ru/jour/article/view/262 |
| work_keys_str_mv | AT mggordienko preparationofsphericalmicroparticlesfrombiodegradablenaturalandsyntheticpolymersfortheirapplicationinregenerativemedicine AT tnsomov preparationofsphericalmicroparticlesfrombiodegradablenaturalandsyntheticpolymersfortheirapplicationinregenerativemedicine AT ysyusupova preparationofsphericalmicroparticlesfrombiodegradablenaturalandsyntheticpolymersfortheirapplicationinregenerativemedicine AT nichupikova preparationofsphericalmicroparticlesfrombiodegradablenaturalandsyntheticpolymersfortheirapplicationinregenerativemedicine AT nvmenshutina preparationofsphericalmicroparticlesfrombiodegradablenaturalandsyntheticpolymersfortheirapplicationinregenerativemedicine |