Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes
Pericytes are pluripotent cells that can be found in the vascular wall of both microvessels and large arteries and veins. They have distinct morphology with long branching processes and form numerous contacts with each other and with endothelial cells, organizing the vascular wall cells into a three...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7321404 |
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| author | Ekaterina A. Ivanova Alexander N. Orekhov |
| author_facet | Ekaterina A. Ivanova Alexander N. Orekhov |
| author_sort | Ekaterina A. Ivanova |
| collection | DOAJ |
| description | Pericytes are pluripotent cells that can be found in the vascular wall of both microvessels and large arteries and veins. They have distinct morphology with long branching processes and form numerous contacts with each other and with endothelial cells, organizing the vascular wall cells into a three-dimensional network. Accumulating evidence demonstrates that pericytes may play a key role in the pathogenesis of vascular disorders, including atherosclerosis. Macrovascular pericytes are able to accumulate lipids and contribute to growth and vascularization of the atherosclerotic plaque. Moreover, they participate in the local inflammatory process and thrombosis, which can lead to fatal consequences. At the same time, pericytes can represent a useful model for studying the atherosclerotic process and for the development of novel therapeutic approaches. In particular, they are suitable for testing various substances’ potential for decreasing lipid accumulation induced by the incubation of cells with atherogenic low-density lipoprotein. In this review we will discuss the application of cellular models for studying atherosclerosis and provide several examples of successful application of these models to drug research. |
| format | Article |
| id | doaj-art-1de44ad5db35459ebcf13c9ca1f3779c |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1de44ad5db35459ebcf13c9ca1f3779c2025-08-20T02:01:39ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/73214047321404Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall PericytesEkaterina A. Ivanova0Alexander N. Orekhov1Department of Development and Regeneration, KU Leuven, 3000 Leuven, BelgiumLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow 125315, RussiaPericytes are pluripotent cells that can be found in the vascular wall of both microvessels and large arteries and veins. They have distinct morphology with long branching processes and form numerous contacts with each other and with endothelial cells, organizing the vascular wall cells into a three-dimensional network. Accumulating evidence demonstrates that pericytes may play a key role in the pathogenesis of vascular disorders, including atherosclerosis. Macrovascular pericytes are able to accumulate lipids and contribute to growth and vascularization of the atherosclerotic plaque. Moreover, they participate in the local inflammatory process and thrombosis, which can lead to fatal consequences. At the same time, pericytes can represent a useful model for studying the atherosclerotic process and for the development of novel therapeutic approaches. In particular, they are suitable for testing various substances’ potential for decreasing lipid accumulation induced by the incubation of cells with atherogenic low-density lipoprotein. In this review we will discuss the application of cellular models for studying atherosclerosis and provide several examples of successful application of these models to drug research.http://dx.doi.org/10.1155/2016/7321404 |
| spellingShingle | Ekaterina A. Ivanova Alexander N. Orekhov Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes Stem Cells International |
| title | Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes |
| title_full | Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes |
| title_fullStr | Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes |
| title_full_unstemmed | Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes |
| title_short | Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes |
| title_sort | cellular model of atherogenesis based on pluripotent vascular wall pericytes |
| url | http://dx.doi.org/10.1155/2016/7321404 |
| work_keys_str_mv | AT ekaterinaaivanova cellularmodelofatherogenesisbasedonpluripotentvascularwallpericytes AT alexandernorekhov cellularmodelofatherogenesisbasedonpluripotentvascularwallpericytes |