Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues
The article discusses the current prevalence of hypercholesterolemia in everyday clinical practice in patients of different risk categories and approaches to its correction in the most frequently used clinical guidelines. High prevalence of hypercholesterolemia in practical health care with little c...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2019-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1809 |
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| author | N. M. Akhmedzhanov D. V. Nebieridze A. S. Safaryan |
| author_facet | N. M. Akhmedzhanov D. V. Nebieridze A. S. Safaryan |
| author_sort | N. M. Akhmedzhanov |
| collection | DOAJ |
| description | The article discusses the current prevalence of hypercholesterolemia in everyday clinical practice in patients of different risk categories and approaches to its correction in the most frequently used clinical guidelines. High prevalence of hypercholesterolemia in practical health care with little change over time is shown. The existing problems of the practical implementation of the principles of a healthy lifestyle as the basis for reducing cardiovascular risk and possible solutions are described. Attention is focused on a low number of patients taking statins, and even less – reaching recommended target cholesterol levels. It is emphasized the validity of lower, compared to previous, target cholesterol levels in National recommendations on the correction of dyslipidemia in patients with proven atherosclerosis-related cardiovascular diseases as well as the feasibility in some cases of combined lipidlowering therapy (statins in combination with intestinal cholesterol absorption blockers, PCSK9 inhibitors, high doses of ethyl eicosopentaenoic acid). It is commented the need to prescribe statins in persons older than 75 years, but with a careful approach. Particular attention is paid to the use of statins in the primary prevention of cardiovascular complications. The validity of prescribing fixed moderate doses of statins for this purpose is discussed, which is both scientifically based and more realistic in practical terms. |
| format | Article |
| id | doaj-art-1de17133b57941d2a80684ed842647ed |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-1de17133b57941d2a80684ed842647ed2025-08-23T10:00:30ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532019-01-0114691792110.20996/1819-6446-2018-14-6-917-9211558Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial IssuesN. M. Akhmedzhanov0D. V. Nebieridze1A. S. Safaryan2National Research Center for Preventive MedicineNational Research Center for Preventive MedicineNational Research Center for Preventive MedicineThe article discusses the current prevalence of hypercholesterolemia in everyday clinical practice in patients of different risk categories and approaches to its correction in the most frequently used clinical guidelines. High prevalence of hypercholesterolemia in practical health care with little change over time is shown. The existing problems of the practical implementation of the principles of a healthy lifestyle as the basis for reducing cardiovascular risk and possible solutions are described. Attention is focused on a low number of patients taking statins, and even less – reaching recommended target cholesterol levels. It is emphasized the validity of lower, compared to previous, target cholesterol levels in National recommendations on the correction of dyslipidemia in patients with proven atherosclerosis-related cardiovascular diseases as well as the feasibility in some cases of combined lipidlowering therapy (statins in combination with intestinal cholesterol absorption blockers, PCSK9 inhibitors, high doses of ethyl eicosopentaenoic acid). It is commented the need to prescribe statins in persons older than 75 years, but with a careful approach. Particular attention is paid to the use of statins in the primary prevention of cardiovascular complications. The validity of prescribing fixed moderate doses of statins for this purpose is discussed, which is both scientifically based and more realistic in practical terms.https://www.rpcardio.online/jour/article/view/1809hypercholesterolemiastatinsprimary and secondary prevention |
| spellingShingle | N. M. Akhmedzhanov D. V. Nebieridze A. S. Safaryan Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues Рациональная фармакотерапия в кардиологии hypercholesterolemia statins primary and secondary prevention |
| title | Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues |
| title_full | Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues |
| title_fullStr | Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues |
| title_full_unstemmed | Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues |
| title_short | Correction of Hypercholesterolemia in Primary and Secondary Prevention of Cardiovascular Diseases: Features and Controversial Issues |
| title_sort | correction of hypercholesterolemia in primary and secondary prevention of cardiovascular diseases features and controversial issues |
| topic | hypercholesterolemia statins primary and secondary prevention |
| url | https://www.rpcardio.online/jour/article/view/1809 |
| work_keys_str_mv | AT nmakhmedzhanov correctionofhypercholesterolemiainprimaryandsecondarypreventionofcardiovasculardiseasesfeaturesandcontroversialissues AT dvnebieridze correctionofhypercholesterolemiainprimaryandsecondarypreventionofcardiovasculardiseasesfeaturesandcontroversialissues AT assafaryan correctionofhypercholesterolemiainprimaryandsecondarypreventionofcardiovasculardiseasesfeaturesandcontroversialissues |