Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson
Parkinson's disease (PD) is less known as a disease causing pain syndromes, although pain is found in 40-80 % of PD patients, as described by the very few reports in this area of research. Moreover, in some PD patients, pain is so severe and intractable that it overshadows the motor symptoms of...
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| Format: | Article |
| Language: | English |
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Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2015-06-01
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| Series: | Medicamentul Veterinar |
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| Online Access: | http://www.veterinarypharmacon.com/docs/1535-2015_VD_ART_6.EN.pdf |
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| author | Daniela Carmen Ababei R. Lefter Veronica Bild Iulia Antioch Ioana Balmus A. Ciobica D. Timofte |
| author_facet | Daniela Carmen Ababei R. Lefter Veronica Bild Iulia Antioch Ioana Balmus A. Ciobica D. Timofte |
| author_sort | Daniela Carmen Ababei |
| collection | DOAJ |
| description | Parkinson's disease (PD) is less known as a disease causing pain syndromes, although pain is found in 40-80 % of PD patients, as described by the very few reports in this area of research. Moreover, in some PD patients, pain is so severe and intractable that it overshadows the motor symptoms of the disorder. Still, pain in PD frequently goes under acknowledged and undertreated. Also, the studies regarding pain perception in the existing animal models of PD are very few. We experimentally induced the PD model in rats by injecting subcutaneously one dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 20mg/kg, while the control group received saline. The behavioral testing for pain included the hot-plate task and was performed 7 days after MPTP injection. In this way, our rat model resulted from the acute treatment with a low dose of MPTP, exhibited an increased sensitivity to pain perception, as demonstrated by the significant decrease in the values of the latency time in hot-plate for rats treated with MPTP, as compared to the controls. In this way, further studies in this area of research seem warranted. |
| format | Article |
| id | doaj-art-1ddf9886b7964b9c80c57ad3aaa18f8e |
| institution | Kabale University |
| issn | 1843-9527 2069-2463 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj-art-1ddf9886b7964b9c80c57ad3aaa18f8e2025-08-20T03:34:05ZengAsociaţia Naţională a Fabricanţilor de Produse de Uz VeterinarMedicamentul Veterinar1843-95272069-24632015-06-01915962Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii ParkinsonDaniela Carmen Ababei0R. Lefter 1Veronica Bild2Iulia Antioch 3Ioana Balmus4A. Ciobica5D. Timofte6Gr. T. Popa ” Medicine and Pharmacy University, IasiRomanian Academy Iasi BranchGr. T. Popa ” Medicine and Pharmacy University, IasiAlexandru Ioan Cuza” University of IasAlexandru Ioan Cuza” University of IasAlexandru Ioan Cuza” University of IasGr. T. Popa ” Medicine and Pharmacy University, IasiParkinson's disease (PD) is less known as a disease causing pain syndromes, although pain is found in 40-80 % of PD patients, as described by the very few reports in this area of research. Moreover, in some PD patients, pain is so severe and intractable that it overshadows the motor symptoms of the disorder. Still, pain in PD frequently goes under acknowledged and undertreated. Also, the studies regarding pain perception in the existing animal models of PD are very few. We experimentally induced the PD model in rats by injecting subcutaneously one dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 20mg/kg, while the control group received saline. The behavioral testing for pain included the hot-plate task and was performed 7 days after MPTP injection. In this way, our rat model resulted from the acute treatment with a low dose of MPTP, exhibited an increased sensitivity to pain perception, as demonstrated by the significant decrease in the values of the latency time in hot-plate for rats treated with MPTP, as compared to the controls. In this way, further studies in this area of research seem warranted.http://www.veterinarypharmacon.com/docs/1535-2015_VD_ART_6.EN.pdfpainParkinson's disease1-methyl-4-phenyl-1236-tetrahydropyridinerat |
| spellingShingle | Daniela Carmen Ababei R. Lefter Veronica Bild Iulia Antioch Ioana Balmus A. Ciobica D. Timofte Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson Medicamentul Veterinar pain Parkinson's disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine rat |
| title | Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson |
| title_full | Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson |
| title_fullStr | Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson |
| title_full_unstemmed | Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson |
| title_short | Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson |
| title_sort | date preliminare privind unele manifestari ale durerii intr un model de sobolan mptp indus a bolii parkinson |
| topic | pain Parkinson's disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine rat |
| url | http://www.veterinarypharmacon.com/docs/1535-2015_VD_ART_6.EN.pdf |
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