Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation
We report an extremely rare case of an alpha-fetoprotein- (AFP-) producing female primary urethral adenocarcinoma with neuroendocrine differentiation (NED). The patient was a 65-year-old woman with a 2-year history of urinary frequency and voiding difficulty. Enhanced computed tomography showed an a...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2019/3454037 |
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| _version_ | 1832555094716973056 |
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| author | Takao Natsuyama Yozo Mitsui Masato Uetani Shigeyuki Ohta Masafumi Inoue Koichiro Akakura |
| author_facet | Takao Natsuyama Yozo Mitsui Masato Uetani Shigeyuki Ohta Masafumi Inoue Koichiro Akakura |
| author_sort | Takao Natsuyama |
| collection | DOAJ |
| description | We report an extremely rare case of an alpha-fetoprotein- (AFP-) producing female primary urethral adenocarcinoma with neuroendocrine differentiation (NED). The patient was a 65-year-old woman with a 2-year history of urinary frequency and voiding difficulty. Enhanced computed tomography showed an approximately 3.0×5.0-cm mass around the proximal urethra and bladder neck. Of examined tumor markers, serum AFP was elevated (48.3 ng/mL), while others including carcinoembryonic antigen were within a normal range. Transurethral resection of the tumor led to a diagnosis of carcinosarcoma of the urethra, with a radical cystourethrectomy and ileal conduit formation subsequently performed. The pathological assessment was poorly differentiated adenocarcinoma in the urethra. Immunostaining showed tumor cells strongly positive for AFP. In addition, some cancer cells were positive for CD56, chromogranin A, and synaptophysin, indicating focal NED. The tumor was finally diagnosed as an AFP-producing urethral adenocarcinoma with NED. Serum AFP was immediately normalized after surgery and no sign of tumor recurrence has been noted 2 years postoperatively. |
| format | Article |
| id | doaj-art-1ddf898de18a4409abc945328abc2c32 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-1ddf898de18a4409abc945328abc2c322025-02-03T05:49:35ZengWileyCase Reports in Urology2090-696X2090-69782019-01-01201910.1155/2019/34540373454037Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine DifferentiationTakao Natsuyama0Yozo Mitsui1Masato Uetani2Shigeyuki Ohta3Masafumi Inoue4Koichiro Akakura5Department of Urology, Chiba-Nishi General Hospital, 270-2251 Chiba, JapanDepartment of Urology, Chiba-Nishi General Hospital, 270-2251 Chiba, JapanDepartment of Urology, Chiba-Nishi General Hospital, 270-2251 Chiba, JapanDepartment of Urology, Chiba-Nishi General Hospital, 270-2251 Chiba, JapanDepartment of Pathology, Japan Community Health Care Organization, Tokyo Shinjuku Medical Center, Tokyo, JapanDepartment of Urology, Japan Community Health Care Organization, Tokyo Shinjuku Medical Center, Tokyo, JapanWe report an extremely rare case of an alpha-fetoprotein- (AFP-) producing female primary urethral adenocarcinoma with neuroendocrine differentiation (NED). The patient was a 65-year-old woman with a 2-year history of urinary frequency and voiding difficulty. Enhanced computed tomography showed an approximately 3.0×5.0-cm mass around the proximal urethra and bladder neck. Of examined tumor markers, serum AFP was elevated (48.3 ng/mL), while others including carcinoembryonic antigen were within a normal range. Transurethral resection of the tumor led to a diagnosis of carcinosarcoma of the urethra, with a radical cystourethrectomy and ileal conduit formation subsequently performed. The pathological assessment was poorly differentiated adenocarcinoma in the urethra. Immunostaining showed tumor cells strongly positive for AFP. In addition, some cancer cells were positive for CD56, chromogranin A, and synaptophysin, indicating focal NED. The tumor was finally diagnosed as an AFP-producing urethral adenocarcinoma with NED. Serum AFP was immediately normalized after surgery and no sign of tumor recurrence has been noted 2 years postoperatively.http://dx.doi.org/10.1155/2019/3454037 |
| spellingShingle | Takao Natsuyama Yozo Mitsui Masato Uetani Shigeyuki Ohta Masafumi Inoue Koichiro Akakura Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation Case Reports in Urology |
| title | Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation |
| title_full | Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation |
| title_fullStr | Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation |
| title_full_unstemmed | Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation |
| title_short | Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation |
| title_sort | alfa fetoprotein producing female primary urethral adenocarcinoma with neuroendocrine differentiation |
| url | http://dx.doi.org/10.1155/2019/3454037 |
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