En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience
En-bloc kidney transplantation from low-weight pediatric donors (≤5 kg) is a challenging procedure performed only in limited transplant centers. We retrospectively analyzed the data from 42 en-bloc kidney transplants from donors weighing less than 5 kg between September 2014 and September 2023. The...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14451/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849326748085256192 |
|---|---|
| author | Xianpeng Zeng Qiuxiang Xia Heng Li Miao Wang Hanying Li Liang He Hua Su Chun Zhang Zhendi Wang |
| author_facet | Xianpeng Zeng Qiuxiang Xia Heng Li Miao Wang Hanying Li Liang He Hua Su Chun Zhang Zhendi Wang |
| author_sort | Xianpeng Zeng |
| collection | DOAJ |
| description | En-bloc kidney transplantation from low-weight pediatric donors (≤5 kg) is a challenging procedure performed only in limited transplant centers. We retrospectively analyzed the data from 42 en-bloc kidney transplants from donors weighing less than 5 kg between September 2014 and September 2023. The mean donor body weight was found to be 3.1 ± 1.0 kg, and the minimum weight was 0.9 kg. At a mean follow-up period of 1,481 days, the graft survival rate was 76.2% and the recipient survival rate was 100.0%. Thrombosis and acute rejection were the major complications responsible for the short-term graft loss. Male recipients were more likely to experience graft loss than female ones (P < 0.05). Recipients with long-term (>1 year) graft survival were observed to have a high prevalence (31.3%) of delayed graft function. However, they still had satisfactory long-term graft function and limited proteinuria. Continuous graft volume growth took more than 1 year to reach a stable level. Lower donor/recipient body surface area may lead to higher delayed graft function and slower estimated glomerular filtration rate recovery (P < 0.05). Kidney transplant from low-weight pediatric donors is associated with a high incidence of short-term graft loss, while long-term outcomes are generally acceptable. |
| format | Article |
| id | doaj-art-1ddf110e27ad4b919d76bcd847d6ba6a |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-1ddf110e27ad4b919d76bcd847d6ba6a2025-08-20T03:48:03ZengFrontiers Media S.A.Transplant International1432-22772025-05-013810.3389/ti.2025.1445114451En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center ExperienceXianpeng Zeng0Qiuxiang Xia1Heng Li2Miao Wang3Hanying Li4Liang He5Hua Su6Chun Zhang7Zhendi Wang8Department of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Hepatobiliary Surgery, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Nephrology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Nephrology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaDepartment of Urology, Huazhong University of Science and Technology Union Hospital, Wuhan, ChinaEn-bloc kidney transplantation from low-weight pediatric donors (≤5 kg) is a challenging procedure performed only in limited transplant centers. We retrospectively analyzed the data from 42 en-bloc kidney transplants from donors weighing less than 5 kg between September 2014 and September 2023. The mean donor body weight was found to be 3.1 ± 1.0 kg, and the minimum weight was 0.9 kg. At a mean follow-up period of 1,481 days, the graft survival rate was 76.2% and the recipient survival rate was 100.0%. Thrombosis and acute rejection were the major complications responsible for the short-term graft loss. Male recipients were more likely to experience graft loss than female ones (P < 0.05). Recipients with long-term (>1 year) graft survival were observed to have a high prevalence (31.3%) of delayed graft function. However, they still had satisfactory long-term graft function and limited proteinuria. Continuous graft volume growth took more than 1 year to reach a stable level. Lower donor/recipient body surface area may lead to higher delayed graft function and slower estimated glomerular filtration rate recovery (P < 0.05). Kidney transplant from low-weight pediatric donors is associated with a high incidence of short-term graft loss, while long-term outcomes are generally acceptable.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14451/fullen-blocgraft failurekidney transplantationthrombosisacute rejection |
| spellingShingle | Xianpeng Zeng Qiuxiang Xia Heng Li Miao Wang Hanying Li Liang He Hua Su Chun Zhang Zhendi Wang En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience Transplant International en-bloc graft failure kidney transplantation thrombosis acute rejection |
| title | En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience |
| title_full | En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience |
| title_fullStr | En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience |
| title_full_unstemmed | En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience |
| title_short | En-Bloc Kidney Transplantation From Extremely Low-Weight (0.9–5.0 kg) Pediatric Donors: A Decade of Single-Center Experience |
| title_sort | en bloc kidney transplantation from extremely low weight 0 9 5 0 kg pediatric donors a decade of single center experience |
| topic | en-bloc graft failure kidney transplantation thrombosis acute rejection |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14451/full |
| work_keys_str_mv | AT xianpengzeng enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT qiuxiangxia enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT hengli enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT miaowang enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT hanyingli enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT lianghe enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT huasu enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT chunzhang enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience AT zhendiwang enblockidneytransplantationfromextremelylowweight0950kgpediatricdonorsadecadeofsinglecenterexperience |