Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study
Abstract Effects of the initial peritoneal dialysis (PD) prescription on clinical outcomes are unknown in Japan. We conducted a cohort study using data from Peritoneal Dialysis Outcomes and Practice Patterns Study. The patients were divided into two groups by the volume of the initial PD prescriptio...
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| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81934-6 |
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| author | Tsutomu Sakurada Junhui Zhao Charlotte Tu Brian Bieber Melissa Cheetham Ronald L. Pisoni Jeffrey Perl Ken Tsuchiya Hideki Kawanishi Jun Minakuchi |
| author_facet | Tsutomu Sakurada Junhui Zhao Charlotte Tu Brian Bieber Melissa Cheetham Ronald L. Pisoni Jeffrey Perl Ken Tsuchiya Hideki Kawanishi Jun Minakuchi |
| author_sort | Tsutomu Sakurada |
| collection | DOAJ |
| description | Abstract Effects of the initial peritoneal dialysis (PD) prescription on clinical outcomes are unknown in Japan. We conducted a cohort study using data from Peritoneal Dialysis Outcomes and Practice Patterns Study. The patients were divided into two groups by the volume of the initial PD prescription (≤ 4 L/day or > 4 L/day). Cause-specific Cox proportional hazards survival models were used to model the association between different PD prescriptions and the clinical outcomes. The outcomes included transfer to HD, mortality, the composite of mortality and transfer to HD, peritonitis, hospitalization, and the patient-reported outcomes (PROs). Of the 342 patients, 98 were prescribed ≤ 4 L/day, and 244 were prescribed > 4 L/day. Patients prescribed ≤ 4 L/day were older with a lower percentage being male, had more cardiovascular and cerebrovascular disease but lower diabetes prevalence, were more likely to be receiving CAPD, used more assisted PD, and had lower BMI and mean serum creatinine levels. There were no significant differences between groups in terms of transfer to HD, mortality, transfer to HD or mortality, hospitalization, incidence of peritonitis, and PROs. Patients with initial PD prescriptions of ≤ 4 L/day compared to > 4 L/day had similar clinical outcomes. This practice may provide health economic benefits in Japan. |
| format | Article |
| id | doaj-art-1ddd1b9fa7a141f5b624fef0967e6a62 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1ddd1b9fa7a141f5b624fef0967e6a622024-12-08T12:30:55ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-81934-6Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort studyTsutomu Sakurada0Junhui Zhao1Charlotte Tu2Brian Bieber3Melissa Cheetham4Ronald L. Pisoni5Jeffrey Perl6Ken Tsuchiya7Hideki Kawanishi8Jun Minakuchi9St. Marianna University School of MedicineArbor Research Collaborative for HealthArbor Research Collaborative for HealthArbor Research Collaborative for HealthSunshine Coast University HospitalArbor Research Collaborative for HealthSt. Michael’s HospitalTokyo Women’s Medical UniversityTsuchiya General HospitalKawashima HospitalAbstract Effects of the initial peritoneal dialysis (PD) prescription on clinical outcomes are unknown in Japan. We conducted a cohort study using data from Peritoneal Dialysis Outcomes and Practice Patterns Study. The patients were divided into two groups by the volume of the initial PD prescription (≤ 4 L/day or > 4 L/day). Cause-specific Cox proportional hazards survival models were used to model the association between different PD prescriptions and the clinical outcomes. The outcomes included transfer to HD, mortality, the composite of mortality and transfer to HD, peritonitis, hospitalization, and the patient-reported outcomes (PROs). Of the 342 patients, 98 were prescribed ≤ 4 L/day, and 244 were prescribed > 4 L/day. Patients prescribed ≤ 4 L/day were older with a lower percentage being male, had more cardiovascular and cerebrovascular disease but lower diabetes prevalence, were more likely to be receiving CAPD, used more assisted PD, and had lower BMI and mean serum creatinine levels. There were no significant differences between groups in terms of transfer to HD, mortality, transfer to HD or mortality, hospitalization, incidence of peritonitis, and PROs. Patients with initial PD prescriptions of ≤ 4 L/day compared to > 4 L/day had similar clinical outcomes. This practice may provide health economic benefits in Japan.https://doi.org/10.1038/s41598-024-81934-6Peritoneal dialysis prescriptionMortalityPeritonitisTransfer to hemodialysisIncremental peritoneal dialysis |
| spellingShingle | Tsutomu Sakurada Junhui Zhao Charlotte Tu Brian Bieber Melissa Cheetham Ronald L. Pisoni Jeffrey Perl Ken Tsuchiya Hideki Kawanishi Jun Minakuchi Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study Scientific Reports Peritoneal dialysis prescription Mortality Peritonitis Transfer to hemodialysis Incremental peritoneal dialysis |
| title | Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study |
| title_full | Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study |
| title_fullStr | Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study |
| title_full_unstemmed | Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study |
| title_short | Effects of initial peritoneal dialysis prescription on clinical outcomes in Japanese peritoneal dialysis patients: a cohort study |
| title_sort | effects of initial peritoneal dialysis prescription on clinical outcomes in japanese peritoneal dialysis patients a cohort study |
| topic | Peritoneal dialysis prescription Mortality Peritonitis Transfer to hemodialysis Incremental peritoneal dialysis |
| url | https://doi.org/10.1038/s41598-024-81934-6 |
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