Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
Introduction: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-in fectious difficulties. Although the potential benefits of EIN are w...
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Medycyna Praktyczna
2022-11-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
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| Online Access: | https://www.mp.pl/videosurgery/issue/article/16740/ |
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| author | Hongxia Li Shaofang Zhang Lin Lin Sanjay Rastogi |
| author_facet | Hongxia Li Shaofang Zhang Lin Lin Sanjay Rastogi |
| author_sort | Hongxia Li |
| collection | DOAJ |
| description | Introduction: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and
nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-in
fectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be
of much help, and hence valid conclusions about its role are still unclear.
Aim: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC).
Material and methods: Appropriate articles were searched from the PubMed, Medline, and Central databases using
the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective,
and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for
the effect of EIN on patients undergoing surgery for GC were extracted from the included studies.
Results: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We
found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a t2 value of 2.77, a c2
value of 1707.96, a df value of 11, an I2 value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk
ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of t2 value of 0.73, c2 value of 1428.34, df value of 11, I2 value
of 99%, z value of 2.99, and p-value < 0.05.
Conclusions: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer
(GC) patients undergoing gastrectomy. |
| format | Article |
| id | doaj-art-1ddb8435b772449996bdb4df084a7ca5 |
| institution | Kabale University |
| issn | 1895-4588 2299-0054 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Medycyna Praktyczna |
| record_format | Article |
| series | Videosurgery and Other Miniinvasive Techniques |
| spelling | doaj-art-1ddb8435b772449996bdb4df084a7ca52025-08-20T03:25:00ZengMedycyna PraktycznaVideosurgery and Other Miniinvasive Techniques1895-45882299-00542022-11-01181314110.5114/wiitm.2022.12076848080Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis Hongxia Li0Shaofang Zhang1 Lin Lin2Sanjay Rastogi3Interventional Operating Room, Yantaishan Hospital, Yantai, Shandong, ChinaDepartment of Hepatology Ward I, Yantai Qishan Hospital, Shandong Province, Yantai, Shandong, ChinaDepartment of Urology, Hospital of Traditional Chinese and Western Medicine of Taizhou, Wenling, Zhejiang, ChinaConsultant, ESIC Model Hospital, Guwahati, Assam, India Introduction: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-in fectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. Aim: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC). Material and methods: Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies. Results: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a t2 value of 2.77, a c2 value of 1707.96, a df value of 11, an I2 value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of t2 value of 0.73, c2 value of 1428.34, df value of 11, I2 value of 99%, z value of 2.99, and p-value < 0.05. Conclusions: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy.https://www.mp.pl/videosurgery/issue/article/16740/gastric cancersurgeryimmunitynutritiongastrectomyenteral immunonutrition |
| spellingShingle | Hongxia Li Shaofang Zhang Lin Lin Sanjay Rastogi Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis Videosurgery and Other Miniinvasive Techniques gastric cancer surgery immunity nutrition gastrectomy enteral immunonutrition |
| title | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
| title_full | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
| title_fullStr | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
| title_full_unstemmed | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
| title_short | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
| title_sort | does enteral immune nutrition ein boost the immunity of gastric cancer gc patients undergoing surgery a systematic review and meta analysis |
| topic | gastric cancer surgery immunity nutrition gastrectomy enteral immunonutrition |
| url | https://www.mp.pl/videosurgery/issue/article/16740/ |
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