The Host Genetic Diversity in Malaria Infection
Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations ass...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/940616 |
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| author | Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto |
| author_facet | Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto |
| author_sort | Vitor R. R. de Mendonça |
| collection | DOAJ |
| description | Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome. Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. The results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against Plasmodium infection. However, these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations. With the recent advances in molecular biology techniques, more robust studies with reliable data have been reported, and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment. |
| format | Article |
| id | doaj-art-1dd88a2cd8904dfb83621c9da89e64b0 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-1dd88a2cd8904dfb83621c9da89e64b02025-02-03T06:44:37ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/940616940616The Host Genetic Diversity in Malaria InfectionVitor R. R. de Mendonça0Marilda Souza Goncalves1Manoel Barral-Netto2Laboratório Integrado de Microbiologia e Imunorregulação (LIMI), CPqGM, FIOCRUZ, Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, BrazilLaboratório Integrado de Microbiologia e Imunorregulação (LIMI), CPqGM, FIOCRUZ, Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, BrazilLaboratório Integrado de Microbiologia e Imunorregulação (LIMI), CPqGM, FIOCRUZ, Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, BrazilPopulations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome. Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. The results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against Plasmodium infection. However, these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations. With the recent advances in molecular biology techniques, more robust studies with reliable data have been reported, and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment.http://dx.doi.org/10.1155/2012/940616 |
| spellingShingle | Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto The Host Genetic Diversity in Malaria Infection Journal of Tropical Medicine |
| title | The Host Genetic Diversity in Malaria Infection |
| title_full | The Host Genetic Diversity in Malaria Infection |
| title_fullStr | The Host Genetic Diversity in Malaria Infection |
| title_full_unstemmed | The Host Genetic Diversity in Malaria Infection |
| title_short | The Host Genetic Diversity in Malaria Infection |
| title_sort | host genetic diversity in malaria infection |
| url | http://dx.doi.org/10.1155/2012/940616 |
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