Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Abstract Intracellular delivery of protein and RNA therapeutics represents a major challenge. Here, we develop highly potent engineered extracellular vesicles (EVs) by incorporating bio-inspired attributes required for effective delivery. These comprise an engineered mini-intein protein with self-cl...

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Main Authors: Xiuming Liang, Dhanu Gupta, Junhua Xie, Elien Van Wonterghem, Lien Van Hoecke, Justin Hean, Zheyu Niu, Marziyeh Ghaeidamini, Oscar P. B. Wiklander, Wenyi Zheng, Rim Jawad Wiklander, Rui He, Doste R. Mamand, Jeremy Bost, Guannan Zhou, Houze Zhou, Samantha Roudi, H. Yesid Estupiñán, Julia Rädler, Antje M. Zickler, André Görgens, Vicky W. Q. Hou, Radka Slovak, Daniel W. Hagey, Olivier G. de Jong, Aileen Geobee Uy, Yuanyuan Zong, Imre Mäger, Carla Martin Perez, Thomas C. Roberts, Dave Carter, Pieter Vader, Elin K. Esbjörner, Antonin de Fougerolles, Matthew J. A. Wood, Roosmarijn E. Vandenbroucke, Joel Z. Nordin, Samir EL Andaloussi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59377-y
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