Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury
This study was conducted to evaluate the cardioprotective property of the aqueous extract of lavender flower (LFAE). The myocardial ischemia/reperfusion (I/R) injury of rat was prepared by Langendorff retrograde perfusion technology. The heart was preperfused with K-H solution containing LFAE for 10...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/368376 |
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| author | Dong Wang Xin Guo Mingjie Zhou Jichun Han Bo Han Xiling Sun |
| author_facet | Dong Wang Xin Guo Mingjie Zhou Jichun Han Bo Han Xiling Sun |
| author_sort | Dong Wang |
| collection | DOAJ |
| description | This study was conducted to evaluate the cardioprotective property of the aqueous extract of lavender flower (LFAE). The myocardial ischemia/reperfusion (I/R) injury of rat was prepared by Langendorff retrograde perfusion technology. The heart was preperfused with K-H solution containing LFAE for 10 min before 20 minutes global ischemia, and then the reperfusion with K-H solution was conducted for 45 min. The left ventricular developed pressure (LVDP) and the maximum up/downrate of left ventricular pressure (±dp/dtmax) were recorded by physiological recorder as the myocardial function and the myocardial infarct size was detected by TTC staining. Lactate dehydrogenase (LDH) and creatine kinase (CK) activities in the effluent were measured to determine the myocardial injury degree. The superoxide anion dismutase (SOD) and malondialdehyde (MDA) in myocardial tissue were detected to determine the oxidative stress degree. The results showed that the pretreatment with LFAE significantly decreased the myocardial infarct size and also decreased the LDH, CK activities, and MDA level, while it increased the LVDP, ±dp/dtmax, SOD activities, and the coronary artery flow. Our findings indicated that LFAE could provide protection for heart against the I/R injury which may be related to the improvement of myocardial oxidative stress states. |
| format | Article |
| id | doaj-art-1dd3125d4e234924aadd4c7a99e59e93 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Journal of Chemistry |
| spelling | doaj-art-1dd3125d4e234924aadd4c7a99e59e932025-08-20T02:01:39ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/368376368376Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion InjuryDong Wang0Xin Guo1Mingjie Zhou2Jichun Han3Bo Han4Xiling Sun5Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, ChinaAffiliated Traditional Medical Hospital of Xinjiang Medical University, Urumqi 830000, ChinaShandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, ChinaSchool of Pharmacy, Shihezi University, Shihezi 832002, ChinaSchool of Pharmacy, Shihezi University, Shihezi 832002, ChinaSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai 264000, ChinaThis study was conducted to evaluate the cardioprotective property of the aqueous extract of lavender flower (LFAE). The myocardial ischemia/reperfusion (I/R) injury of rat was prepared by Langendorff retrograde perfusion technology. The heart was preperfused with K-H solution containing LFAE for 10 min before 20 minutes global ischemia, and then the reperfusion with K-H solution was conducted for 45 min. The left ventricular developed pressure (LVDP) and the maximum up/downrate of left ventricular pressure (±dp/dtmax) were recorded by physiological recorder as the myocardial function and the myocardial infarct size was detected by TTC staining. Lactate dehydrogenase (LDH) and creatine kinase (CK) activities in the effluent were measured to determine the myocardial injury degree. The superoxide anion dismutase (SOD) and malondialdehyde (MDA) in myocardial tissue were detected to determine the oxidative stress degree. The results showed that the pretreatment with LFAE significantly decreased the myocardial infarct size and also decreased the LDH, CK activities, and MDA level, while it increased the LVDP, ±dp/dtmax, SOD activities, and the coronary artery flow. Our findings indicated that LFAE could provide protection for heart against the I/R injury which may be related to the improvement of myocardial oxidative stress states.http://dx.doi.org/10.1155/2014/368376 |
| spellingShingle | Dong Wang Xin Guo Mingjie Zhou Jichun Han Bo Han Xiling Sun Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury Journal of Chemistry |
| title | Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury |
| title_full | Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury |
| title_fullStr | Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury |
| title_full_unstemmed | Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury |
| title_short | Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury |
| title_sort | cardioprotective effect of the aqueous extract of lavender flower against myocardial ischemia reperfusion injury |
| url | http://dx.doi.org/10.1155/2014/368376 |
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