The multiple functions of CD5 in diseases related to immune disorders
CD5 is a critical regulator of the immune system and a transmembrane glycoprotein expressed on T cells and the surface of certain B cells. Over the years, numerous studies have demonstrated that CD5 is involved in the regulation of immune responses, maintenance of immune tolerance, and modulation of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2519682 |
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| author | Jiawen Dong Kaibo Zhang Jinhui Hong Jialu Ye Leping Wang Qiang Ke Yuyang Ye Keting Jin Yalun Chen Jing Wu |
| author_facet | Jiawen Dong Kaibo Zhang Jinhui Hong Jialu Ye Leping Wang Qiang Ke Yuyang Ye Keting Jin Yalun Chen Jing Wu |
| author_sort | Jiawen Dong |
| collection | DOAJ |
| description | CD5 is a critical regulator of the immune system and a transmembrane glycoprotein expressed on T cells and the surface of certain B cells. Over the years, numerous studies have demonstrated that CD5 is involved in the regulation of immune responses, maintenance of immune tolerance, and modulation of cell survival and apoptosis. Beyond these functions, CD5 also plays a role in immunotherapy, recognition of pathogen-associated molecular patterns, regulation of inflammatory processes, prediction of poor tumour prognosis, and clearance of macromolecules. Immune aberrant disorders—such as infections, chronic inflammation, malignancies, and autoimmune diseases—arise when the immune system becomes dysregulated. This study outlines the diverse and extensive biological functions of CD5 in relation to immunological abnormalities. A deeper understanding of CD5’s specific roles in disease is expected to shed light on the complex pathophysiology of these conditions and may reveal novel therapeutic strategies and interventions for the management of immune-related disorders. |
| format | Article |
| id | doaj-art-1dd2c29e99a449d4b27fb7b0eded87b1 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-1dd2c29e99a449d4b27fb7b0eded87b12025-08-20T02:10:19ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2519682The multiple functions of CD5 in diseases related to immune disordersJiawen Dong0Kaibo Zhang1Jinhui Hong2Jialu Ye3Leping Wang4Qiang Ke5Yuyang Ye6Keting Jin7Yalun Chen8Jing Wu9Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaSchool of Medicine, Lishui University, Zhejiang, ChinaDepartment of Medical Laboratory Medicine, The Fourth People’ s Hospital of Lin’an District, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaCD5 is a critical regulator of the immune system and a transmembrane glycoprotein expressed on T cells and the surface of certain B cells. Over the years, numerous studies have demonstrated that CD5 is involved in the regulation of immune responses, maintenance of immune tolerance, and modulation of cell survival and apoptosis. Beyond these functions, CD5 also plays a role in immunotherapy, recognition of pathogen-associated molecular patterns, regulation of inflammatory processes, prediction of poor tumour prognosis, and clearance of macromolecules. Immune aberrant disorders—such as infections, chronic inflammation, malignancies, and autoimmune diseases—arise when the immune system becomes dysregulated. This study outlines the diverse and extensive biological functions of CD5 in relation to immunological abnormalities. A deeper understanding of CD5’s specific roles in disease is expected to shed light on the complex pathophysiology of these conditions and may reveal novel therapeutic strategies and interventions for the management of immune-related disorders.https://www.tandfonline.com/doi/10.1080/07853890.2025.2519682CD5lymphocyteimmune dysfunctiondiseasemultiple role |
| spellingShingle | Jiawen Dong Kaibo Zhang Jinhui Hong Jialu Ye Leping Wang Qiang Ke Yuyang Ye Keting Jin Yalun Chen Jing Wu The multiple functions of CD5 in diseases related to immune disorders Annals of Medicine CD5 lymphocyte immune dysfunction disease multiple role |
| title | The multiple functions of CD5 in diseases related to immune disorders |
| title_full | The multiple functions of CD5 in diseases related to immune disorders |
| title_fullStr | The multiple functions of CD5 in diseases related to immune disorders |
| title_full_unstemmed | The multiple functions of CD5 in diseases related to immune disorders |
| title_short | The multiple functions of CD5 in diseases related to immune disorders |
| title_sort | multiple functions of cd5 in diseases related to immune disorders |
| topic | CD5 lymphocyte immune dysfunction disease multiple role |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2519682 |
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