Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model
SUMMARY: Bacterial chondronecrosis with osteomyelitis (BCO) lameness has been a major concern in the broiler industry, causing financial losses and animal welfare issues. BCO lameness is caused by a bacterial infection in leg bones. Pathogens enter the bloodstream via respiratory and intestinal epit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Applied Poultry Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1056617124001053 |
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| author | Khawla Alharbi Andi Asnayanti Amer Hasan Wesley J. Vaught Kathrin Buehler Jan Dirk Van der Klis Javier Gonzalez Michael T. Kidd Adnan Alrubaye |
| author_facet | Khawla Alharbi Andi Asnayanti Amer Hasan Wesley J. Vaught Kathrin Buehler Jan Dirk Van der Klis Javier Gonzalez Michael T. Kidd Adnan Alrubaye |
| author_sort | Khawla Alharbi |
| collection | DOAJ |
| description | SUMMARY: Bacterial chondronecrosis with osteomyelitis (BCO) lameness has been a major concern in the broiler industry, causing financial losses and animal welfare issues. BCO lameness is caused by a bacterial infection in leg bones. Pathogens enter the bloodstream via respiratory and intestinal epithelial translocation and infect the tibia and femoral heads of the birds. Supplementation of 1,25(OH)2D3 is crucial in regulating calcium and phosphorus homeostasis, immune system, and bone metabolism. 1,25(OH)2D3 glycosides derived from Solanum glaucophyllum (G-1,25(OH)2D3) were hypothesized to mitigate BCO lameness in broilers. In this study, G-1,25(OH)2D3 alone or in combination with phytogenic antioxidants were tested for their impacts on cumulative BCO lameness in the broiler population. BCO seeder group and the negative control had developed 78,0% and 73.5% cumulative lameness (P = 0.64), respectively. Supplementation of 1 µg/kg of G-1,25(OH)2D3 was more effective in reducing the cumulative lameness than 10 µg/kg of G-1,25(OH)2D3 (P < 0.05). There were no significant differences between 1 µg/kg of G-1,25(OH)2D3 alone or in combination with 500 mg/kg of a mixture of Curcuma longa plus Trachyspermum ammi (PH1), 750 mg/kg of a mixture of Solanum xanthacarpum plus Piper longum (PH2), or 500 mg/kg thyme oil. Therefore, 1 µg/kg of G-1,25(OH)2D3 provided better protection against BCO lameness compared to 10 µg/kg of G-1,25(OH)2D3. Additionally, the combination with phytogenic antioxidants did not result in any further reduction of cumulative BCO lameness compared to the use of G-1,25(OH)2D3 alone. |
| format | Article |
| id | doaj-art-1dc9400bcb654aa58ff31dff7945b8cc |
| institution | Kabale University |
| issn | 1056-6171 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Applied Poultry Research |
| spelling | doaj-art-1dc9400bcb654aa58ff31dff7945b8cc2025-01-22T05:41:06ZengElsevierJournal of Applied Poultry Research1056-61712025-03-01341100507Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission modelKhawla Alharbi0Andi Asnayanti1Amer Hasan2Wesley J. Vaught3Kathrin Buehler4Jan Dirk Van der Klis5Javier Gonzalez6Michael T. Kidd7Adnan Alrubaye8Cell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA; Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USACell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA; Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USA; National Agency of Drug and Food Control, Jakarta, IndonesiaCell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA; Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA; Department of Veterinary Public Health, College of Veterinary Medicine, University of Baghdad, Baghdad, IraqDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA; Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USAHerbonis Animal Health GmbH, SwitzerlandHerbonis Animal Health GmbH, SwitzerlandNuproxa, SwitzerlandDepartment of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USACell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA; Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USA; Corresponding author at: John Tyson Center for Excellence in Poultry Science, University of Arkansas, 1260 W. Maple Street, Fayetteville, Arkansas 72701.SUMMARY: Bacterial chondronecrosis with osteomyelitis (BCO) lameness has been a major concern in the broiler industry, causing financial losses and animal welfare issues. BCO lameness is caused by a bacterial infection in leg bones. Pathogens enter the bloodstream via respiratory and intestinal epithelial translocation and infect the tibia and femoral heads of the birds. Supplementation of 1,25(OH)2D3 is crucial in regulating calcium and phosphorus homeostasis, immune system, and bone metabolism. 1,25(OH)2D3 glycosides derived from Solanum glaucophyllum (G-1,25(OH)2D3) were hypothesized to mitigate BCO lameness in broilers. In this study, G-1,25(OH)2D3 alone or in combination with phytogenic antioxidants were tested for their impacts on cumulative BCO lameness in the broiler population. BCO seeder group and the negative control had developed 78,0% and 73.5% cumulative lameness (P = 0.64), respectively. Supplementation of 1 µg/kg of G-1,25(OH)2D3 was more effective in reducing the cumulative lameness than 10 µg/kg of G-1,25(OH)2D3 (P < 0.05). There were no significant differences between 1 µg/kg of G-1,25(OH)2D3 alone or in combination with 500 mg/kg of a mixture of Curcuma longa plus Trachyspermum ammi (PH1), 750 mg/kg of a mixture of Solanum xanthacarpum plus Piper longum (PH2), or 500 mg/kg thyme oil. Therefore, 1 µg/kg of G-1,25(OH)2D3 provided better protection against BCO lameness compared to 10 µg/kg of G-1,25(OH)2D3. Additionally, the combination with phytogenic antioxidants did not result in any further reduction of cumulative BCO lameness compared to the use of G-1,25(OH)2D3 alone.http://www.sciencedirect.com/science/article/pii/S1056617124001053BroilerBoneBacterial chondronecrosis with osteomyelitisLameness1,25(OH)2D3 |
| spellingShingle | Khawla Alharbi Andi Asnayanti Amer Hasan Wesley J. Vaught Kathrin Buehler Jan Dirk Van der Klis Javier Gonzalez Michael T. Kidd Adnan Alrubaye Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model Journal of Applied Poultry Research Broiler Bone Bacterial chondronecrosis with osteomyelitis Lameness 1,25(OH)2D3 |
| title | Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| title_full | Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| title_fullStr | Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| title_full_unstemmed | Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| title_short | Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| title_sort | investigating the effect of 1 25 dihydroxycholecalciferol glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model |
| topic | Broiler Bone Bacterial chondronecrosis with osteomyelitis Lameness 1,25(OH)2D3 |
| url | http://www.sciencedirect.com/science/article/pii/S1056617124001053 |
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