Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis

Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis

Abstract Intervertebral disc degeneration (IVDD) and its attendant lower back pain are a major medical challenge. Ferroptosis has become a new target for the treatment of IVDD. Mesenchymal stem cells (MSCs) are a promising regenerative therapy for IVDD. Hydrogel is usually used as a delivery carrier...

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Bibliographic Details
Main Authors: Song Fu, Renhua Lv, Longqiang Wang, Zhenyu Wang, Fengming Wang, Hao Gao, Wei Zhao, Xiaoling Huang, Xiaojun Li, Yanan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Intervertebral disc degeneration
Bone mesenchymal stem cell
Matric hydrogels
Ferroptosis
STAT3
Online Access:https://doi.org/10.1038/s41598-025-00278-x
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