Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries
Background and aims: The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO). Methods and results: Thirty-nine ASO patients (age...
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Elsevier
2024-12-01
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| Series: | International Journal of Cardiology Congenital Heart Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666668524000594 |
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| author | Art Schuermans Béatrice Santens Jef Van den Eynde Xander Jacquemyn Roel L.F. Van der Palen Michael C. Honigberg Alexander Van De Bruaene Piet Claus Jan Bogaert Werner Budts |
| author_facet | Art Schuermans Béatrice Santens Jef Van den Eynde Xander Jacquemyn Roel L.F. Van der Palen Michael C. Honigberg Alexander Van De Bruaene Piet Claus Jan Bogaert Werner Budts |
| author_sort | Art Schuermans |
| collection | DOAJ |
| description | Background and aims: The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO). Methods and results: Thirty-nine ASO patients (age 24.4 ± 3.3 years) were included during routine clinical follow-up from July 2019 to December 2021. All patients underwent cardiopulmonary exercise testing and cardiac magnetic resonance imaging at rest and during exercise. Early-life characteristics, including birth weight, were extracted from electronic medical health records. Linear regression analysis showed that lower birth weight was associated with smaller left ventricular (LV) and right ventricular (RV) end-diastolic volume index (LV: −14.5 mL/m2 [95 % confidence interval, CI: −26.5 to −2.5] per 1-kg decrease in birth weight, p = 0.04; RV: −11.2 mL/m2 [-20.7 to −1.7] per 1-kg decrease in birth weight, p = 0.03). Lower birth weight was associated with greater LV and RV ejection fraction at rest (LV: +8.5 % [+4.4 to +12.5] per 1-kg decrease in birth weight, p < 0.001); RV: +8.1 % [+2.8 to +13.4] per 1-kg decrease in birth weight, p = 0.005). Furthermore, lower birth weight was associated with an attenuated increase in LV stroke volume index from rest to peak exercise (−5.2 mL/m2 [-9.3 to −1.2] per 1-kg decrease in birth weight, p = 0.02). Conclusions: Birth weight may be a novel risk factor for adverse cardiac remodeling in adult ASO patients. Further research is needed to delineate the mechanisms underlying the associations between birth weight and cardiac remodeling ASO patients as well as the broader adult CHD population. |
| format | Article |
| id | doaj-art-1dc7711b5d5041aba0ddc2e38583b95d |
| institution | OA Journals |
| issn | 2666-6685 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | International Journal of Cardiology Congenital Heart Disease |
| spelling | doaj-art-1dc7711b5d5041aba0ddc2e38583b95d2025-08-20T01:52:45ZengElsevierInternational Journal of Cardiology Congenital Heart Disease2666-66852024-12-011810055010.1016/j.ijcchd.2024.100550Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteriesArt Schuermans0Béatrice Santens1Jef Van den Eynde2Xander Jacquemyn3Roel L.F. Van der Palen4Michael C. Honigberg5Alexander Van De Bruaene6Piet Claus7Jan Bogaert8Werner Budts9Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USADepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Congenital and Structural Cardiology, UZ Leuven, Leuven, BelgiumDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Congenital and Structural Cardiology, UZ Leuven, Leuven, BelgiumDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Helen B. Taussig Heart Center, Johns Hopkins Hospital and School of Medicine, Baltimore, MD, USADepartment of Pediatrics, Division of Pediatric Cardiology, Leiden University Medical Centre LUMC, Leiden, the NetherlandsProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USADepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Congenital and Structural Cardiology, UZ Leuven, Leuven, BelgiumDepartment of Cardiovascular Sciences, KU Leuven, Leuven, BelgiumDepartment of Radiology, UZ Leuven, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Leuven, BelgiumDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Congenital and Structural Cardiology, UZ Leuven, Leuven, Belgium; Corresponding author. Congenital and Structural Cardiology, UZ Leuven, Herestraat 49, B-3000, Leuven, Belgium.Background and aims: The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO). Methods and results: Thirty-nine ASO patients (age 24.4 ± 3.3 years) were included during routine clinical follow-up from July 2019 to December 2021. All patients underwent cardiopulmonary exercise testing and cardiac magnetic resonance imaging at rest and during exercise. Early-life characteristics, including birth weight, were extracted from electronic medical health records. Linear regression analysis showed that lower birth weight was associated with smaller left ventricular (LV) and right ventricular (RV) end-diastolic volume index (LV: −14.5 mL/m2 [95 % confidence interval, CI: −26.5 to −2.5] per 1-kg decrease in birth weight, p = 0.04; RV: −11.2 mL/m2 [-20.7 to −1.7] per 1-kg decrease in birth weight, p = 0.03). Lower birth weight was associated with greater LV and RV ejection fraction at rest (LV: +8.5 % [+4.4 to +12.5] per 1-kg decrease in birth weight, p < 0.001); RV: +8.1 % [+2.8 to +13.4] per 1-kg decrease in birth weight, p = 0.005). Furthermore, lower birth weight was associated with an attenuated increase in LV stroke volume index from rest to peak exercise (−5.2 mL/m2 [-9.3 to −1.2] per 1-kg decrease in birth weight, p = 0.02). Conclusions: Birth weight may be a novel risk factor for adverse cardiac remodeling in adult ASO patients. Further research is needed to delineate the mechanisms underlying the associations between birth weight and cardiac remodeling ASO patients as well as the broader adult CHD population.http://www.sciencedirect.com/science/article/pii/S2666668524000594Cardiac remodelingCongenital heart diseaseMagnetic resonance imagingPrematurityTransposition of the great arteriesArterial switch operation |
| spellingShingle | Art Schuermans Béatrice Santens Jef Van den Eynde Xander Jacquemyn Roel L.F. Van der Palen Michael C. Honigberg Alexander Van De Bruaene Piet Claus Jan Bogaert Werner Budts Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries International Journal of Cardiology Congenital Heart Disease Cardiac remodeling Congenital heart disease Magnetic resonance imaging Prematurity Transposition of the great arteries Arterial switch operation |
| title | Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| title_full | Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| title_fullStr | Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| title_full_unstemmed | Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| title_short | Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| title_sort | low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries |
| topic | Cardiac remodeling Congenital heart disease Magnetic resonance imaging Prematurity Transposition of the great arteries Arterial switch operation |
| url | http://www.sciencedirect.com/science/article/pii/S2666668524000594 |
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