The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction
Abstract Background Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients. Objective The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment. Methods The study s...
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BMC
2025-01-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03201-z |
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| author | Lixin Xu Jianfeng Lin Jianke Xia Deng Chen Guohan He |
| author_facet | Lixin Xu Jianfeng Lin Jianke Xia Deng Chen Guohan He |
| author_sort | Lixin Xu |
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| description | Abstract Background Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients. Objective The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment. Methods The study subjects were 90 AMI patients and 50 acute chest pain patients (control). All patients were examined by echocardiography and recorded LVEDV, LVESV, and LVEF. RT-qPCR was performed to detect the serum miR-199a-5p level. Pearson analysis was used to analyze the correlation of miR-199a-5p with LVEF and cTnI. The diagnostic value of miR-199a-5p combined with LVEDV, LVESV, and LVEF was assessed by the ROC curve. The occurrence of major adverse cardiovascular events (MACE) was recorded to analyze the prognostic value of miR-199a-5p by the Kaplan-Meier curve and Cox regression. Results Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. The combination of miR-199a-5p with LVEDV, LVESV, and LVEF enhanced the sensitivity and specificity for the diagnosis of AMI. Patients with high miR-199a-5p expression were more likely to develop MACE. The combination of miR-199a-5p with LVEF improved the prediction of MACE. Conclusions The combination of miR-199a-5p with echocardiography improved the diagnostic efficiency of AMI and provided prognostic information. |
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| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-1dc58dbce24841268be40dd7e86810b42025-01-12T12:38:59ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011710.1186/s13019-024-03201-zThe diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarctionLixin Xu0Jianfeng Lin1Jianke Xia2Deng Chen3Guohan He4Department of Ultrasound, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Third Affiliated Hospital of Shanghai UniversityDepartment of Cardiology, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Third Affiliated Hospital of Shanghai UniversityDepartment of Ultrasound, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Third Affiliated Hospital of Shanghai UniversityDepartment of Ultrasound, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Third Affiliated Hospital of Shanghai UniversityDepartment of Ultrasound, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Third Affiliated Hospital of Shanghai UniversityAbstract Background Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients. Objective The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment. Methods The study subjects were 90 AMI patients and 50 acute chest pain patients (control). All patients were examined by echocardiography and recorded LVEDV, LVESV, and LVEF. RT-qPCR was performed to detect the serum miR-199a-5p level. Pearson analysis was used to analyze the correlation of miR-199a-5p with LVEF and cTnI. The diagnostic value of miR-199a-5p combined with LVEDV, LVESV, and LVEF was assessed by the ROC curve. The occurrence of major adverse cardiovascular events (MACE) was recorded to analyze the prognostic value of miR-199a-5p by the Kaplan-Meier curve and Cox regression. Results Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. The combination of miR-199a-5p with LVEDV, LVESV, and LVEF enhanced the sensitivity and specificity for the diagnosis of AMI. Patients with high miR-199a-5p expression were more likely to develop MACE. The combination of miR-199a-5p with LVEF improved the prediction of MACE. Conclusions The combination of miR-199a-5p with echocardiography improved the diagnostic efficiency of AMI and provided prognostic information.https://doi.org/10.1186/s13019-024-03201-zAMImiR-199a-5pEchocardiographyDiagnosisMACE |
| spellingShingle | Lixin Xu Jianfeng Lin Jianke Xia Deng Chen Guohan He The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction Journal of Cardiothoracic Surgery AMI miR-199a-5p Echocardiography Diagnosis MACE |
| title | The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction |
| title_full | The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction |
| title_fullStr | The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction |
| title_full_unstemmed | The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction |
| title_short | The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction |
| title_sort | diagnostic and prognostic value of serum mir 199a 5p combined with echocardiography in acute myocardial infarction |
| topic | AMI miR-199a-5p Echocardiography Diagnosis MACE |
| url | https://doi.org/10.1186/s13019-024-03201-z |
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