Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer
High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage...
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PAGEPress Publications
2025-01-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3174 |
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| author | Sinem İnan Semra Bilaçeroğlu Burcu Uludağ Artun |
| author_facet | Sinem İnan Semra Bilaçeroğlu Burcu Uludağ Artun |
| author_sort | Sinem İnan |
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High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement/invasion. A total of 105 lung cancer and 120 control patients (chronic obstructive lung disease, interstitial lung disease, pulmonary thromboembolism, and pneumonia; 30/subgroup) with measured NT-proBNP levels were included retrospectively. Demographics, comorbidities, and echocardiographic findings in all patients, as well as histologic subtype, diameter, stage, and radiologic and/or pathologic mediastinal involvement/invasion of the tumor to the mediastinum in patients with lung cancer, were studied with regards to blood NT-proBNP levels. When lung cancer and control groups were compared globally or as subgroups with comorbidities, NT-proBNP levels did not show meaningful differences. However, NT-proBNP levels were determined to be 249 pg/mL and 88 pg/mL in lung cancer (n=68) and control subgroups (n=58) without comorbidities, respectively (p=0.001). Among lung cancer patients without comorbidities and those with cardiac, pericardial, major vascular, or other mediastinal involvement/invasion (lymphadenopathy, lymphatic, or other organ invasion) (n=27), the NT-proBNP level was 303 pg/mL, whereas it was 166 pg/mL in those without these mediastinal invasions (n=41) (p=0.031). There is a need for much larger, randomized studies to obtain evidence for the potential role of NT-proBNP as a helpful diagnostic biomarker for lung cancer. Clinical suspicion of malignancy may be posed if high NT-proBNP levels cannot be explained by all other risk factors and disorders or diseases. Furthermore, pericardial, cardiac, major vessel, or other mediastinal invasion/involvement should be sought when high NT-proBNP levels are determined in lung cancer patients without any comorbidities or risk factors for high NT-proBNP levels.
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| format | Article |
| id | doaj-art-1dc4b945d20f4d4f938d168823612b15 |
| institution | Kabale University |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-1dc4b945d20f4d4f938d168823612b152025-01-28T01:39:42ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-01-0110.4081/monaldi.2025.3174Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancerSinem İnan0https://orcid.org/0000-0001-9708-7488Semra Bilaçeroğlu1https://orcid.org/0000-0002-9703-9598Burcu Uludağ Artun2https://orcid.org/0000-0003-2178-6308Department of Allergy and Immunology, Izmir City Hospital, IzmirDepartment of Pulmonology, Izmir Faculty of Medicine, University of Health Sciences, IzmirDepartment of Cardiology, Izmir City Hospital, Izmir High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement/invasion. A total of 105 lung cancer and 120 control patients (chronic obstructive lung disease, interstitial lung disease, pulmonary thromboembolism, and pneumonia; 30/subgroup) with measured NT-proBNP levels were included retrospectively. Demographics, comorbidities, and echocardiographic findings in all patients, as well as histologic subtype, diameter, stage, and radiologic and/or pathologic mediastinal involvement/invasion of the tumor to the mediastinum in patients with lung cancer, were studied with regards to blood NT-proBNP levels. When lung cancer and control groups were compared globally or as subgroups with comorbidities, NT-proBNP levels did not show meaningful differences. However, NT-proBNP levels were determined to be 249 pg/mL and 88 pg/mL in lung cancer (n=68) and control subgroups (n=58) without comorbidities, respectively (p=0.001). Among lung cancer patients without comorbidities and those with cardiac, pericardial, major vascular, or other mediastinal involvement/invasion (lymphadenopathy, lymphatic, or other organ invasion) (n=27), the NT-proBNP level was 303 pg/mL, whereas it was 166 pg/mL in those without these mediastinal invasions (n=41) (p=0.031). There is a need for much larger, randomized studies to obtain evidence for the potential role of NT-proBNP as a helpful diagnostic biomarker for lung cancer. Clinical suspicion of malignancy may be posed if high NT-proBNP levels cannot be explained by all other risk factors and disorders or diseases. Furthermore, pericardial, cardiac, major vessel, or other mediastinal invasion/involvement should be sought when high NT-proBNP levels are determined in lung cancer patients without any comorbidities or risk factors for high NT-proBNP levels. https://www.monaldi-archives.org/macd/article/view/3174Lung cancerN-terminal pro-brain natriuretic peptidemediastinal invasioncomorbiditytumor stagetumor histology |
| spellingShingle | Sinem İnan Semra Bilaçeroğlu Burcu Uludağ Artun Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer Monaldi Archives for Chest Disease Lung cancer N-terminal pro-brain natriuretic peptide mediastinal invasion comorbidity tumor stage tumor histology |
| title | Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer |
| title_full | Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer |
| title_fullStr | Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer |
| title_full_unstemmed | Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer |
| title_short | Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer |
| title_sort | significance of n terminal pro b type natriuretic peptide levels in lung cancer |
| topic | Lung cancer N-terminal pro-brain natriuretic peptide mediastinal invasion comorbidity tumor stage tumor histology |
| url | https://www.monaldi-archives.org/macd/article/view/3174 |
| work_keys_str_mv | AT sineminan significanceofnterminalprobtypenatriureticpeptidelevelsinlungcancer AT semrabilaceroglu significanceofnterminalprobtypenatriureticpeptidelevelsinlungcancer AT burcuuludagartun significanceofnterminalprobtypenatriureticpeptidelevelsinlungcancer |