Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations
Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other...
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2018-06-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/823 |
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| author | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev |
| author_facet | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases.Objective: to estimate the degree of synergism between different combinations of GS and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs.Results and discussion. Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time.Conclusion. The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases. |
| format | Article |
| id | doaj-art-1dc0a728c1a74eb69759f4bb8607926f |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2018-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-1dc0a728c1a74eb69759f4bb8607926f2025-08-20T03:59:56ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-06-01122364310.14412/1996-7012-2018-2-36-432090Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinationsO. A. Gromova0I. Yu. Torshin1A. M. Lila2A. V. Naumov3I. A. Reier4A. E. Karateev5Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of SciencesInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of SciencesV.A. Nasonova Research Institute of RheumatologyRussian Gerontology Research and Clinical CenterInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of SciencesV.A. Nasonova Research Institute of RheumatologyGlucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases.Objective: to estimate the degree of synergism between different combinations of GS and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs.Results and discussion. Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time.Conclusion. The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases.https://mrj.ima-press.net/mrj/article/view/823glucosamine sulfatesustaquard artroketorolacnimesulidedexketoprofenmeloxicamdiclofenaccelecoxibetoricoxibdatabase mining |
| spellingShingle | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations Современная ревматология glucosamine sulfate sustaquard artro ketorolac nimesulide dexketoprofen meloxicam diclofenac celecoxib etoricoxib database mining |
| title | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_full | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_fullStr | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_full_unstemmed | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_short | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_sort | differential chemoreactome analysis of glucosamine sulfate and non steroidal anti inflammatory drugs promising synergistic drug combinations |
| topic | glucosamine sulfate sustaquard artro ketorolac nimesulide dexketoprofen meloxicam diclofenac celecoxib etoricoxib database mining |
| url | https://mrj.ima-press.net/mrj/article/view/823 |
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