Development of a Lentiviral Reporter System for In Vitro Reprogramming of Astrocytes to Neuronal Precursors

Development of a Lentiviral Reporter System for In Vitro Reprogramming of Astrocytes to Neuronal Precursors

Astrocytes, which proliferate after brain injury, represent a promising target for cellular reprogramming due to their abundance and ability to support brain repair. In this study, we investigated the in vitro reprogramming of primary cortical astrocytes from neonatal rats into neuronal precursor ce...

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Bibliographic Details
Main Authors: Anna Schnaubelt, Guoli Zheng, Maryam Hatami, Johannes Tödt, Hao Wang, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger, Alexander Younsi
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
astrocyte reprogramming
neuron conversion
neuronal precursor cells
Oct4
Sox2
Klf4
Online Access:https://www.mdpi.com/2079-7737/14/7/817
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