Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is a serious condition that can lead to long-term neurological damage. Mild hypothermia is a promising treatment for HIE, but its efficacy and safety in newborns are not well established. To evaluate the therapeutic effects of mild hypotherm...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Duan Wenfeng Wang Xuan |
| author_facet | Duan Wenfeng Wang Xuan |
| author_sort | Duan Wenfeng |
| collection | DOAJ |
| description | Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is a serious condition that can lead to long-term neurological damage. Mild hypothermia is a promising treatment for HIE, but its efficacy and safety in newborns are not well established. To evaluate the therapeutic effects of mild hypothermia on neonatal HIE in a randomised controlled trial. Methods: This was a prospective study of 132 newborns with HIE treated with either mild hypothermia or routine conventional treatment. The primary outcome measures were changes in neural cytokines, brain injury markers, oxidative stress factors, neurological function recovery time, and therapeutic outcomes. Results: The mild hypothermia group showed significant improvements in neural cytokines (NGF and BDNF), brain injury markers (S100B, NSE, and MBP), and oxidative stress factors (SOD, MDA, IL-18, and caspase-3) compared to the control group. The mild hypothermia group also had a faster neurological function recovery time and a higher total response rate (95.45% vs. 80.30%, P<0.05) compared to the control group. Conclusions: Mild hypothermia therapy is a safe and effective treatment for neonatal HIE, with significant improvements in neural cytokines, brain injury markers, and oxidative stress factors, as well as faster neurological function recovery time and higher therapeutic outcomes. Results: The mild hypothermia group showed significant improvements in neural cytokines (NGF and BDNF), brain injury markers (S100B, NSE, and MBP), and oxidative stress factors (SOD, MDA, IL-18, and caspase-3) compared to the control group. The mild hypothermia group also had a faster neurological function recovery time and a higher total response rate (95.45% vs. 80.30%, P<0.05) compared to the control group. Conclusions: Mild hypothermia therapy is a safe and effective treatment for neonatal HIE, with significant improvements in neural cytokines, brain injury markers, and oxidative stress factors, as well as faster neurological function recovery time and higher therapeutic outcomes. The novelty of this work was that it showed potential biomarkers for evaluating response to treatment and the pathophysiological effect of treatment by assessing these biomarkers. |
| format | Article |
| id | doaj-art-1dba2a71d68540e1a50ebd97342afcb7 |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-1dba2a71d68540e1a50ebd97342afcb72025-08-20T02:44:38ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144351552310.5937/jomb0-508661452-82582503515DMild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathyDuan Wenfeng0Wang Xuan1Northwest Women's and Children's Hospital, Department of Neonatology, Xi'an, Shaanxi Province, China521 Hospital of Norinco Group, Department of Neonatal, Xi'an, Shaanxi Province, ChinaBackground: Neonatal hypoxic-ischemic encephalopathy (HIE) is a serious condition that can lead to long-term neurological damage. Mild hypothermia is a promising treatment for HIE, but its efficacy and safety in newborns are not well established. To evaluate the therapeutic effects of mild hypothermia on neonatal HIE in a randomised controlled trial. Methods: This was a prospective study of 132 newborns with HIE treated with either mild hypothermia or routine conventional treatment. The primary outcome measures were changes in neural cytokines, brain injury markers, oxidative stress factors, neurological function recovery time, and therapeutic outcomes. Results: The mild hypothermia group showed significant improvements in neural cytokines (NGF and BDNF), brain injury markers (S100B, NSE, and MBP), and oxidative stress factors (SOD, MDA, IL-18, and caspase-3) compared to the control group. The mild hypothermia group also had a faster neurological function recovery time and a higher total response rate (95.45% vs. 80.30%, P<0.05) compared to the control group. Conclusions: Mild hypothermia therapy is a safe and effective treatment for neonatal HIE, with significant improvements in neural cytokines, brain injury markers, and oxidative stress factors, as well as faster neurological function recovery time and higher therapeutic outcomes. Results: The mild hypothermia group showed significant improvements in neural cytokines (NGF and BDNF), brain injury markers (S100B, NSE, and MBP), and oxidative stress factors (SOD, MDA, IL-18, and caspase-3) compared to the control group. The mild hypothermia group also had a faster neurological function recovery time and a higher total response rate (95.45% vs. 80.30%, P<0.05) compared to the control group. Conclusions: Mild hypothermia therapy is a safe and effective treatment for neonatal HIE, with significant improvements in neural cytokines, brain injury markers, and oxidative stress factors, as well as faster neurological function recovery time and higher therapeutic outcomes. The novelty of this work was that it showed potential biomarkers for evaluating response to treatment and the pathophysiological effect of treatment by assessing these biomarkers.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503515D.pdfneonatal hielevels of cytokinesneurobehavioral score |
| spellingShingle | Duan Wenfeng Wang Xuan Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy Journal of Medical Biochemistry neonatal hie levels of cytokines neurobehavioral score |
| title | Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy |
| title_full | Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy |
| title_fullStr | Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy |
| title_full_unstemmed | Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy |
| title_short | Mild hypothermia effects on serum neuroprotection, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and superoxide dismutase (SOD) levels in neonates with hypoxic-ischemic encephalopathy |
| title_sort | mild hypothermia effects on serum neuroprotection nerve growth factor ngf brain derived neurotrophic factor bdnf and superoxide dismutase sod levels in neonates with hypoxic ischemic encephalopathy |
| topic | neonatal hie levels of cytokines neurobehavioral score |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503515D.pdf |
| work_keys_str_mv | AT duanwenfeng mildhypothermiaeffectsonserumneuroprotectionnervegrowthfactorngfbrainderivedneurotrophicfactorbdnfandsuperoxidedismutasesodlevelsinneonateswithhypoxicischemicencephalopathy AT wangxuan mildhypothermiaeffectsonserumneuroprotectionnervegrowthfactorngfbrainderivedneurotrophicfactorbdnfandsuperoxidedismutasesodlevelsinneonateswithhypoxicischemicencephalopathy |