SPTBN1 overexpression ameliorates atherosclerosis by inhibiting oxidative stress and inflammation via regulating the TRIM37/TRAF2/NF-κB pathway

Abstract Background Endothelial cell apoptosis and oxidative stress are pivotal drivers of atherosclerosis (AS) progression. It was revealed that spectrin beta, non-erythrocytic 1 (SPTBN1) levels were remarkably decreased in the atherosclerotic plaque vessels of advanced lesions. This study aimed to...

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Bibliographic Details
Main Authors: Senyan Wu, Xiaoni Tan, Guobing Cheng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Online Access:https://doi.org/10.1186/s40001-025-02994-6
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