Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

Abstract Background Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in the development of osteolysis, with endoplasmic reticul...

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Main Authors: Xin Yu, Juan Jiang, Cheng Li, Yang Wang, Zhengrong Ren, Jianlun Hu, Tao Yuan, Yongjie Wu, Dongsheng Wang, Ziying Sun, Qi Wu, Bin Chen, Peng Fang, Hao Ding, Jia Meng, Hui Jiang, Jianning Zhao, Nirong Bao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Osthole
Aseptic loosening
Osteolysis
Osteoblast
ER stress
PERK signaling cascade
Online Access:https://doi.org/10.1186/s10020-024-01034-z
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