Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products
Ionizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy. Clustered DNA lesions, often induced by low-energy electrons (LEEs), contribute significantly to genomic instability and repai...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Genetic Engineering and Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1687157X25000459 |
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| author | Kouass Sahbani Saloua Rayan M. Alansari |
| author_facet | Kouass Sahbani Saloua Rayan M. Alansari |
| author_sort | Kouass Sahbani Saloua |
| collection | DOAJ |
| description | Ionizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy. Clustered DNA lesions, often induced by low-energy electrons (LEEs), contribute significantly to genomic instability and repair resistance. Chemotherapeutic agents like cisplatin can enhance IR-induced damage, making tumor cells more susceptible. Emerging strategies in radiation oncology target DNA repair pathways, using inhibitors like poly(ADP-ribose) polymerase (PARP) to sensitize tumors to IR. Natural products, including polyphenols, flavonoids, and alkaloids, offer promising radioprotective effects by scavenging reactive oxygen species and enhancing DNA repair. These agents not only protect normal tissues but also increase tumor sensitivity to IR, improving therapeutic outcomes. Future research should focus on optimizing these natural agents for clinical use, integrating them into radiotherapy protocols for enhanced efficacy and reduced toxicity. |
| format | Article |
| id | doaj-art-1db22fb7d85347a780251fb8b636d0a2 |
| institution | Kabale University |
| issn | 1687-157X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Genetic Engineering and Biotechnology |
| spelling | doaj-art-1db22fb7d85347a780251fb8b636d0a22025-08-20T03:52:24ZengElsevierJournal of Genetic Engineering and Biotechnology1687-157X2025-06-0123210050110.1016/j.jgeb.2025.100501Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural productsKouass Sahbani Saloua0Rayan M. Alansari1Department of Nuclear Medicine & Radiobiology, Faculty of medicine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Faculty of Applied Medical Science AlUla, Department of Nursing, Taibah University, Saudi Arabia; Corresponding author at: Faculty of Applied Medical Science AlUla, Department of Nursing, Taibah University, Saudi Arabia.Faculty of Sciences, Taibah University, Saudi ArabiaIonizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy. Clustered DNA lesions, often induced by low-energy electrons (LEEs), contribute significantly to genomic instability and repair resistance. Chemotherapeutic agents like cisplatin can enhance IR-induced damage, making tumor cells more susceptible. Emerging strategies in radiation oncology target DNA repair pathways, using inhibitors like poly(ADP-ribose) polymerase (PARP) to sensitize tumors to IR. Natural products, including polyphenols, flavonoids, and alkaloids, offer promising radioprotective effects by scavenging reactive oxygen species and enhancing DNA repair. These agents not only protect normal tissues but also increase tumor sensitivity to IR, improving therapeutic outcomes. Future research should focus on optimizing these natural agents for clinical use, integrating them into radiotherapy protocols for enhanced efficacy and reduced toxicity.http://www.sciencedirect.com/science/article/pii/S1687157X25000459Gamma radiationLow energy electronsPlasmid DNA functionalityDSB DNA damage and repairNon-DSB Cluster damageNatural product |
| spellingShingle | Kouass Sahbani Saloua Rayan M. Alansari Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products Journal of Genetic Engineering and Biotechnology Gamma radiation Low energy electrons Plasmid DNA functionality DSB DNA damage and repair Non-DSB Cluster damage Natural product |
| title | Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products |
| title_full | Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products |
| title_fullStr | Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products |
| title_full_unstemmed | Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products |
| title_short | Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products |
| title_sort | impact of ionizing radiation and low energy electrons on dna functionality radioprotection and radiosensitization potential of natural products |
| topic | Gamma radiation Low energy electrons Plasmid DNA functionality DSB DNA damage and repair Non-DSB Cluster damage Natural product |
| url | http://www.sciencedirect.com/science/article/pii/S1687157X25000459 |
| work_keys_str_mv | AT kouasssahbanisaloua impactofionizingradiationandlowenergyelectronsondnafunctionalityradioprotectionandradiosensitizationpotentialofnaturalproducts AT rayanmalansari impactofionizingradiationandlowenergyelectronsondnafunctionalityradioprotectionandradiosensitizationpotentialofnaturalproducts |