Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section
Objective: To analyze efficacy of intrathecal Dexmedetomidine as adjunct to hyperbaric Bupivacaine in terms of postoperative analgesia after caesarean section. Study Design & Setting: This randomized controlled trial was conducted at Department of Anesthesia, Rawal Institute of Health Sciences,...
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| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2022-10-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1009 |
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| author | Ayesha Shahid Huda Shafqat Salman Maqbool Ahsan Ali Rehana Feroze |
| author_facet | Ayesha Shahid Huda Shafqat Salman Maqbool Ahsan Ali Rehana Feroze |
| author_sort | Ayesha Shahid |
| collection | DOAJ |
| description |
Objective: To analyze efficacy of intrathecal Dexmedetomidine as adjunct to hyperbaric Bupivacaine in terms of postoperative analgesia after caesarean section.
Study Design & Setting: This randomized controlled trial was conducted at Department of Anesthesia, Rawal Institute
of Health Sciences, Islamabad from20th, October 2018 to 20thApril 2019 after taking Ethical board approval from the
Institute. (letter no RIHS-REC/030/18, dated, 18th October 2018).
Methodology: Total n=120 patients having ASA status I, II undergoing elective cesarean section were randomly divided
into 2groups (60 each) by lottery method. Group-A, was given hyperbaricBupivacaine (0.5%) 12mg alone and group-B,
was given hyperbaricBupivacaine (0.5%) 12mg along with injection Dexmedetomidine 4ug in intrathecal space respectively.
Patients were followed in postoperative period for onset of pain and requirement for rescue analgesia in first 6 hours.
Results: There was statistically significant difference in mean onset of postoperative pain among both the groups-A and
B (178.18 ± 12.51 versus 364.07± 35.58min respectively with p value 0.000), as well as, postoperative analgesic requirement,
in first 6 hours, 39 (65.0 %) versus 31 (51.7 %) with p-value 0.000 respectively. However, on stratification, considering
effect modifiers, like age (20-30 years and 30-40 year and previous history of cesarean section), there was statistically
significant difference in mean onset of pain in both groups, but no significant difference was found regarding rescue
analgesic requirement in both groups.
Conclusion: Intrathecal Dexmedetomidine along with hyperbaric Bupivacaine was better than hyperbaric Bupivacaine
alone in controlling postoperative pain in caesarean section.
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| format | Article |
| id | doaj-art-1dafdc6cd03f4afb87f2a74df05d43e0 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-1dafdc6cd03f4afb87f2a74df05d43e02025-08-20T02:45:09ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822022-10-01120410.51985/JBUMDC2021111Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean SectionAyesha Shahid Huda ShafqatSalman MaqboolAhsan AliRehana Feroze Objective: To analyze efficacy of intrathecal Dexmedetomidine as adjunct to hyperbaric Bupivacaine in terms of postoperative analgesia after caesarean section. Study Design & Setting: This randomized controlled trial was conducted at Department of Anesthesia, Rawal Institute of Health Sciences, Islamabad from20th, October 2018 to 20thApril 2019 after taking Ethical board approval from the Institute. (letter no RIHS-REC/030/18, dated, 18th October 2018). Methodology: Total n=120 patients having ASA status I, II undergoing elective cesarean section were randomly divided into 2groups (60 each) by lottery method. Group-A, was given hyperbaricBupivacaine (0.5%) 12mg alone and group-B, was given hyperbaricBupivacaine (0.5%) 12mg along with injection Dexmedetomidine 4ug in intrathecal space respectively. Patients were followed in postoperative period for onset of pain and requirement for rescue analgesia in first 6 hours. Results: There was statistically significant difference in mean onset of postoperative pain among both the groups-A and B (178.18 ± 12.51 versus 364.07± 35.58min respectively with p value 0.000), as well as, postoperative analgesic requirement, in first 6 hours, 39 (65.0 %) versus 31 (51.7 %) with p-value 0.000 respectively. However, on stratification, considering effect modifiers, like age (20-30 years and 30-40 year and previous history of cesarean section), there was statistically significant difference in mean onset of pain in both groups, but no significant difference was found regarding rescue analgesic requirement in both groups. Conclusion: Intrathecal Dexmedetomidine along with hyperbaric Bupivacaine was better than hyperbaric Bupivacaine alone in controlling postoperative pain in caesarean section. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1009Cesarean section, Dexmedetomidine, Hyperbaric bupivacaine, Intrathecal space |
| spellingShingle | Ayesha Shahid Huda Shafqat Salman Maqbool Ahsan Ali Rehana Feroze Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section Journal of Bahria University Medical and Dental College Cesarean section, Dexmedetomidine, Hyperbaric bupivacaine, Intrathecal space |
| title | Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section |
| title_full | Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section |
| title_fullStr | Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section |
| title_full_unstemmed | Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section |
| title_short | Determining the Effect of Intrathecal Dexmedetomidine on Postoperative Pain Relief after Cesarean Section |
| title_sort | determining the effect of intrathecal dexmedetomidine on postoperative pain relief after cesarean section |
| topic | Cesarean section, Dexmedetomidine, Hyperbaric bupivacaine, Intrathecal space |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1009 |
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