A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

Increases in cellular Reactive Oxygen Species (ROS) concentration with age have been observed repeatedly in mammalian tissues. Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observed. Populations of mitotic human fibroblasts cultur...

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Bibliographic Details
Main Authors: Conor Lawless, Diana Jurk, Colin S Gillespie, Daryl Shanley, Gabriele Saretzki, Thomas von Zglinicki, João F Passos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032117&type=printable
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