Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients
Aim: ST-elevation myocardial infarction (STEMI) patients suffer higher mortality and adverse outcomes linked to endothelial dysfunction (ED). Methods: 43 patients were randomized to pentoxifylline (PTX) 400 mg thrice daily (n = 22) or placebo (n = 21). Soluble vascular cell adhesion molecule-1, malo...
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0266 |
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| author | Asmaa Saeed Mohamed Moustafa Farouk Nagwa Ali Sabri Mohamed Ayman Saleh Marwa Adel Ahmed |
| author_facet | Asmaa Saeed Mohamed Moustafa Farouk Nagwa Ali Sabri Mohamed Ayman Saleh Marwa Adel Ahmed |
| author_sort | Asmaa Saeed |
| collection | DOAJ |
| description | Aim: ST-elevation myocardial infarction (STEMI) patients suffer higher mortality and adverse outcomes linked to endothelial dysfunction (ED). Methods: 43 patients were randomized to pentoxifylline (PTX) 400 mg thrice daily (n = 22) or placebo (n = 21). Soluble vascular cell adhesion molecule-1, malondialdehyde, interleukin-1 (IL-1), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were assessed at baseline and 2 months. Results: After 2 months, no significant difference was observed in markers' levels between the 2 groups. However, a within-group comparison revealed a statistically significant change in hs-CRP in the PTX group (10.057 (9.779–10.331) versus 9.721 (6.102–10.191)), p = 0.032. Conclusion: PTX for 2 months in STEMI patients was safe and well-tolerated but had no significant detectable effect on ED, oxidative stress or inflammatory markers.Clinical Trial Registration: NCT04367935 (ClinicalTrials.gov) |
| format | Article |
| id | doaj-art-1da8d14e697244ef9c3dfe81c7e9c5b6 |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-1da8d14e697244ef9c3dfe81c7e9c5b62025-08-20T02:40:30ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2023-0266Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patientsAsmaa Saeed0Mohamed Moustafa Farouk1Nagwa Ali Sabri2Mohamed Ayman Saleh3Marwa Adel Ahmed4Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, EgyptDepartment of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, 11591 EgyptDepartment of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, EgyptDepartment of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, 11591 EgyptDepartment of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, EgyptAim: ST-elevation myocardial infarction (STEMI) patients suffer higher mortality and adverse outcomes linked to endothelial dysfunction (ED). Methods: 43 patients were randomized to pentoxifylline (PTX) 400 mg thrice daily (n = 22) or placebo (n = 21). Soluble vascular cell adhesion molecule-1, malondialdehyde, interleukin-1 (IL-1), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were assessed at baseline and 2 months. Results: After 2 months, no significant difference was observed in markers' levels between the 2 groups. However, a within-group comparison revealed a statistically significant change in hs-CRP in the PTX group (10.057 (9.779–10.331) versus 9.721 (6.102–10.191)), p = 0.032. Conclusion: PTX for 2 months in STEMI patients was safe and well-tolerated but had no significant detectable effect on ED, oxidative stress or inflammatory markers.Clinical Trial Registration: NCT04367935 (ClinicalTrials.gov)https://www.tandfonline.com/doi/10.2144/fsoa-2023-0266acute coronary syndromeendothelial dysfunctioninflammationmalondialdehydeoxidative stresspentoxifylline |
| spellingShingle | Asmaa Saeed Mohamed Moustafa Farouk Nagwa Ali Sabri Mohamed Ayman Saleh Marwa Adel Ahmed Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients Future Science OA acute coronary syndrome endothelial dysfunction inflammation malondialdehyde oxidative stress pentoxifylline |
| title | Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients |
| title_full | Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients |
| title_fullStr | Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients |
| title_full_unstemmed | Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients |
| title_short | Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients |
| title_sort | effect of pentoxifylline on endothelial dysfunction oxidative stress and inflammatory markers in stemi patients |
| topic | acute coronary syndrome endothelial dysfunction inflammation malondialdehyde oxidative stress pentoxifylline |
| url | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0266 |
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