Outcome of cataract surgery in juvenile idiopathic arthritis-associated uveitis under two different biological regimens
Aim In this study, we compared the outcome of cataract extraction in patients with juvenile idiopathic arthritis (JIA)-associated uveitis treated with adalimumab (ADA) compared to patients treated with infliximab (IFX). Patients and methods The study included 22 eyes of 22 children with JIA-a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Delta Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/djop/fulltext/2024/25040/outcome_of_cataract_surgery_in_juvenile_idiopathic.3.aspx |
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| Summary: | Aim
In this study, we compared the outcome of cataract extraction in patients with juvenile idiopathic arthritis (JIA)-associated uveitis treated with adalimumab (ADA) compared to patients treated with infliximab (IFX).
Patients and methods
The study included 22 eyes of 22 children with JIA-associated chronic anterior uveitis. The ADA group included 16 patients while the IFX group included six patients. All patients underwent irrigation/aspiration without intraocular lens implantation. The data were collected retrospectively before and 6 months after surgery including best corrected visual acuity (BCVA), intraocular pressure, slit lamp biomicroscopy, and fundus examination. All eyes included in the study had completely inactive intraocular inflammation for 3 months before surgery. The change in BCVA was the main outcome measure.
Results
The two groups were age and sex matched. In the ADA group, there was a statistically significant improvement in the mean LogMAR BCVA from 1.063±0.33 preoperatively to 0.538±0.54 postoperatively (P=0.0085), while in the IFX group the mean BCVA improved from 1.183±0.475 preoperatively to 0.683±0.594 postoperatively, with no statistically significant difference (P=0.068). The difference in the postoperative BCVA between the two groups was not statistically significant (P=0.68). A larger percentage of patients in the IFX group developed postoperative inflammation (33.3 vs. 25%).
Conclusion
The visual acuity improved after cataract extraction in patients with JIA-associated uveitis treated with ADA or IFX, but the improvement was more significant in the patients treated with ADA. |
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| ISSN: | 2090-4835 |