Cystatin C as a potential biomarker to evaluate migraine
ABSTRACT Background: Migraine is a multifactorial neurovascular syndrome and closely associated to inflammation. Cystatin C (Cys C) is a neuroendocrine polypeptide which also plays a role in inflammation. Objective: To investigate the levels of Cys C in migraine patients without aura. Methods: A...
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Thieme Revinter Publicações
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020005011205&lng=en&tlng=en |
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| author | Turan AKDAĞ Ali Ulvi UCA |
| author_facet | Turan AKDAĞ Ali Ulvi UCA |
| author_sort | Turan AKDAĞ |
| collection | DOAJ |
| description | ABSTRACT Background: Migraine is a multifactorial neurovascular syndrome and closely associated to inflammation. Cystatin C (Cys C) is a neuroendocrine polypeptide which also plays a role in inflammation. Objective: To investigate the levels of Cys C in migraine patients without aura. Methods: A total of 80 participants were included in the study; 40 patients and 40 healthy controls. Serum Cys C levels were investigated by using enzyme-linked immunosorbent assay (ELISA). Statistical analysis were performed using Statistical Package for the Social Sciences (SPSS) version 22.0 (SPSS Inc, IL, USA). Results: Serum Cys C levels were found as 73.88 ng/mL in the patient group and 24.92 ng/mL in the healthy control group, being significantly higher among patients (p=0.000). Serum Cys C levels were significacntly different across age subgroups among patients (p=0.049), but not among controls. However, visual analog scale (VAS) (p=0.707), disease duration time (p=0.725) and body mass index (p=0.136) were not significantly different between the two groups. Conclusion: Our findings demonstrate that high serum Cys C levels are independently associated to migraine without aura. To the best of our knowledge, this is the first study to determine the serum levels of Cys C in patients with migraine. Thus, serum Cys C may be a potential biomarker of migraine. |
| format | Article |
| id | doaj-art-1da17e3335b0421c94a48ebaaea56be5 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-1da17e3335b0421c94a48ebaaea56be52025-08-20T02:01:19ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-422710.1590/0004-282x20200005S0004-282X2020005011205Cystatin C as a potential biomarker to evaluate migraineTuran AKDAĞAli Ulvi UCAABSTRACT Background: Migraine is a multifactorial neurovascular syndrome and closely associated to inflammation. Cystatin C (Cys C) is a neuroendocrine polypeptide which also plays a role in inflammation. Objective: To investigate the levels of Cys C in migraine patients without aura. Methods: A total of 80 participants were included in the study; 40 patients and 40 healthy controls. Serum Cys C levels were investigated by using enzyme-linked immunosorbent assay (ELISA). Statistical analysis were performed using Statistical Package for the Social Sciences (SPSS) version 22.0 (SPSS Inc, IL, USA). Results: Serum Cys C levels were found as 73.88 ng/mL in the patient group and 24.92 ng/mL in the healthy control group, being significantly higher among patients (p=0.000). Serum Cys C levels were significacntly different across age subgroups among patients (p=0.049), but not among controls. However, visual analog scale (VAS) (p=0.707), disease duration time (p=0.725) and body mass index (p=0.136) were not significantly different between the two groups. Conclusion: Our findings demonstrate that high serum Cys C levels are independently associated to migraine without aura. To the best of our knowledge, this is the first study to determine the serum levels of Cys C in patients with migraine. Thus, serum Cys C may be a potential biomarker of migraine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020005011205&lng=en&tlng=enmigraine disorderscystatin cheadache |
| spellingShingle | Turan AKDAĞ Ali Ulvi UCA Cystatin C as a potential biomarker to evaluate migraine Arquivos de Neuro-Psiquiatria migraine disorders cystatin c headache |
| title | Cystatin C as a potential biomarker to evaluate migraine |
| title_full | Cystatin C as a potential biomarker to evaluate migraine |
| title_fullStr | Cystatin C as a potential biomarker to evaluate migraine |
| title_full_unstemmed | Cystatin C as a potential biomarker to evaluate migraine |
| title_short | Cystatin C as a potential biomarker to evaluate migraine |
| title_sort | cystatin c as a potential biomarker to evaluate migraine |
| topic | migraine disorders cystatin c headache |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020005011205&lng=en&tlng=en |
| work_keys_str_mv | AT turanakdag cystatincasapotentialbiomarkertoevaluatemigraine AT aliulviuca cystatincasapotentialbiomarkertoevaluatemigraine |