CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC)
Circular RNAs (circRNAs) are a new category of non-coding RNAs implicated in the molecular pathology of cancer, such as oral squamous cell carcinoma (OSCC). Circular intronic RNAs (ciRNAs), exonic circRNAs (ecircRNAs), and exon-intron circRNAs (EIciRNAs) are three primary types of circRNAs resulted...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1555002/full |
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| author | Jun-Lin Lv Jun-Lin Lv Ru Ma Ru Ma Yu-Shan Ren Qing-Yue Liang He-Meng Zhang Gui-Cheng Dong Jie Li |
| author_facet | Jun-Lin Lv Jun-Lin Lv Ru Ma Ru Ma Yu-Shan Ren Qing-Yue Liang He-Meng Zhang Gui-Cheng Dong Jie Li |
| author_sort | Jun-Lin Lv |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are a new category of non-coding RNAs implicated in the molecular pathology of cancer, such as oral squamous cell carcinoma (OSCC). Circular intronic RNAs (ciRNAs), exonic circRNAs (ecircRNAs), and exon-intron circRNAs (EIciRNAs) are three primary types of circRNAs resulted from the circularization of extron and intron which give rise to the distinct biology of circRNAs. Due to their unique structure and biogenesis, circRNAs exhibit tissue- and cell-specific expression profiles. Recent studies have highlighted that in OSCC, some circRNAs are differentially expressed compared with adjacent normal tissues, with these variables potentially influencing OSCC initiation and progression through diverse mechanisms. Furthermore, earlier clinical trials have indicated that circRNAs could be considered as potential therapeutic targets and biomarkers for OSCC. It should be noted that many circRNAs modulate tumor cells proliferation/apoptosis and metastasis via regulating gene transcription and post transcriptional expressions. Furthermore, certain circRNAs function as effective microRNA sponges, thereby inhibiting oncogenic pathways in OSCC. In summary, the discovery of circRNAs has unveiled new avenues for cancer research, particularly in OSCC. This review provides an overview of circRNA biogenesis, their biological functions, and their roles as differentially expressed molecules in OSCC, emphasizing their potential for clinical application and warranting further investigation into their functional and therapeutic relevance. |
| format | Article |
| id | doaj-art-1d9cf7e666a64f1090ce4815050b6dcd |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-1d9cf7e666a64f1090ce4815050b6dcd2025-08-20T02:02:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15550021555002CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC)Jun-Lin Lv0Jun-Lin Lv1Ru Ma2Ru Ma3Yu-Shan Ren4Qing-Yue Liang5He-Meng Zhang6Gui-Cheng Dong7Jie Li8College of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaCollege of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaSchool of Stomatology, Zhangzhou Health Vocational College, Zhangzhou, Fujian, ChinaCollege of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaCollege of Life Sciences, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, ChinaCollege of Life Sciences, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, ChinaCollege of Life Sciences, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, ChinaCollege of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaCircular RNAs (circRNAs) are a new category of non-coding RNAs implicated in the molecular pathology of cancer, such as oral squamous cell carcinoma (OSCC). Circular intronic RNAs (ciRNAs), exonic circRNAs (ecircRNAs), and exon-intron circRNAs (EIciRNAs) are three primary types of circRNAs resulted from the circularization of extron and intron which give rise to the distinct biology of circRNAs. Due to their unique structure and biogenesis, circRNAs exhibit tissue- and cell-specific expression profiles. Recent studies have highlighted that in OSCC, some circRNAs are differentially expressed compared with adjacent normal tissues, with these variables potentially influencing OSCC initiation and progression through diverse mechanisms. Furthermore, earlier clinical trials have indicated that circRNAs could be considered as potential therapeutic targets and biomarkers for OSCC. It should be noted that many circRNAs modulate tumor cells proliferation/apoptosis and metastasis via regulating gene transcription and post transcriptional expressions. Furthermore, certain circRNAs function as effective microRNA sponges, thereby inhibiting oncogenic pathways in OSCC. In summary, the discovery of circRNAs has unveiled new avenues for cancer research, particularly in OSCC. This review provides an overview of circRNA biogenesis, their biological functions, and their roles as differentially expressed molecules in OSCC, emphasizing their potential for clinical application and warranting further investigation into their functional and therapeutic relevance.https://www.frontiersin.org/articles/10.3389/fonc.2025.1555002/fullcircular RNAoral squamous cell carcinomatumorigenesismechanismbiomarkers |
| spellingShingle | Jun-Lin Lv Jun-Lin Lv Ru Ma Ru Ma Yu-Shan Ren Qing-Yue Liang He-Meng Zhang Gui-Cheng Dong Jie Li CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) Frontiers in Oncology circular RNA oral squamous cell carcinoma tumorigenesis mechanism biomarkers |
| title | CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) |
| title_full | CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) |
| title_fullStr | CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) |
| title_full_unstemmed | CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) |
| title_short | CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) |
| title_sort | circrna the potential biomarkers and therapeutic targets in oral squamous cell carcinoma oscc |
| topic | circular RNA oral squamous cell carcinoma tumorigenesis mechanism biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1555002/full |
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