Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, affecting millions annually and posing a significant global health concern. Traditional therapies for UTIs are becoming increasingly ineffective due to rising drug resistance and their tendency to disrupt the h...
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| Format: | Article |
| Language: | English |
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Korean Association of Urogenital Tract Infection and Inflammation
2025-04-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/uti-2448034017.pdf |
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| author | Hoonhee Seo Md Abdur Rahim Indrajeet Barman Mohammed Solayman Hossain Hanieh Tajdozian Fatemeh Ghorbanian Md Sarower Hossen Shuvo Jiho Choi Sukyung Kim Heejo Yang Ho-Yeon Song |
| author_facet | Hoonhee Seo Md Abdur Rahim Indrajeet Barman Mohammed Solayman Hossain Hanieh Tajdozian Fatemeh Ghorbanian Md Sarower Hossen Shuvo Jiho Choi Sukyung Kim Heejo Yang Ho-Yeon Song |
| author_sort | Hoonhee Seo |
| collection | DOAJ |
| description | Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, affecting millions annually and posing a significant global health concern. Traditional therapies for UTIs are becoming increasingly ineffective due to rising drug resistance and their tendency to disrupt the host's healthy microbiota, leading to further side effects. Consequently, there is an urgent need to develop alternative therapeutic agents that differ from conventional regimens and have fewer or no side effects. In this context, microbiome therapeutics offer a promising solution, given their demonstrated efficacy against various infectious diseases. Advances in scientific technology, particularly next-generation sequencing, have deepened our understanding of urinary microbiome dynamics, revealing a complex interplay within the urobiome that influences the onset and progression of UTIs. Uropathogenic bacteria do not solely cause UTIs; shifts in the composition of the urinary microbiome and interactions within the microbial community, known as host-microbiota interactions, also play a significant role. Although recent studies underscore the potential of targeting the urinary microbiome to manage UTIs and related complications, this field is still emerging and faces numerous regulatory and technical challenges. Further in-depth and comprehensive research is required to advance this pioneering concept into clinical practice. |
| format | Article |
| id | doaj-art-1d8449a151fc4752ac1e5cc5778fb7bc |
| institution | Kabale University |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-1d8449a151fc4752ac1e5cc5778fb7bc2025-08-20T03:32:11ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102025-04-0120141610.14777/uti.2448034017430Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative ReviewHoonhee Seo0Md Abdur Rahim1Indrajeet Barman2Mohammed Solayman Hossain3Hanieh Tajdozian4Fatemeh Ghorbanian5Md Sarower Hossen Shuvo6Jiho Choi7Sukyung Kim8Heejo Yang9Ho-Yeon Song10 Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Next-Generation Microbiome Training Center, Soonchunhyang University, Asan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, Korea Department of Urology, School of Medicine, Soonchunhyang University, Cheonan, Korea Human Microbiome Medical Research Center (HMㆍMRC), School of Medicine, Soonchunhyang University, Asan, KoreaUrinary tract infections (UTIs) are among the most common bacterial infections worldwide, affecting millions annually and posing a significant global health concern. Traditional therapies for UTIs are becoming increasingly ineffective due to rising drug resistance and their tendency to disrupt the host's healthy microbiota, leading to further side effects. Consequently, there is an urgent need to develop alternative therapeutic agents that differ from conventional regimens and have fewer or no side effects. In this context, microbiome therapeutics offer a promising solution, given their demonstrated efficacy against various infectious diseases. Advances in scientific technology, particularly next-generation sequencing, have deepened our understanding of urinary microbiome dynamics, revealing a complex interplay within the urobiome that influences the onset and progression of UTIs. Uropathogenic bacteria do not solely cause UTIs; shifts in the composition of the urinary microbiome and interactions within the microbial community, known as host-microbiota interactions, also play a significant role. Although recent studies underscore the potential of targeting the urinary microbiome to manage UTIs and related complications, this field is still emerging and faces numerous regulatory and technical challenges. Further in-depth and comprehensive research is required to advance this pioneering concept into clinical practice.http://euti.org/upload/pdf/uti-2448034017.pdfurinary tract infectionsmicrobiome therapeuticsurobiomeurinary microbiome dynamicshost-microbiota interaction |
| spellingShingle | Hoonhee Seo Md Abdur Rahim Indrajeet Barman Mohammed Solayman Hossain Hanieh Tajdozian Fatemeh Ghorbanian Md Sarower Hossen Shuvo Jiho Choi Sukyung Kim Heejo Yang Ho-Yeon Song Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review Urogenital Tract Infection urinary tract infections microbiome therapeutics urobiome urinary microbiome dynamics host-microbiota interaction |
| title | Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review |
| title_full | Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review |
| title_fullStr | Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review |
| title_full_unstemmed | Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review |
| title_short | Emerging Insights Into Microbiome Therapeutics for Urinary Tract Infections: A Narrative Review |
| title_sort | emerging insights into microbiome therapeutics for urinary tract infections a narrative review |
| topic | urinary tract infections microbiome therapeutics urobiome urinary microbiome dynamics host-microbiota interaction |
| url | http://euti.org/upload/pdf/uti-2448034017.pdf |
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