Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis
Background. There are no treatments with established efficacy for this disorder so far. Aim. To systematically review the efficacy of acotiamide in the treatment of patients with FD. Methods. We searched main electronic databases through November 2013. RCTs evaluating the efficacy of acotiamide vers...
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/541950 |
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| author | Guoguang Xiao Xiaoping Xie Juan Fan Jianjun Deng Shan Tan Yu Zhu Qin Guo Chaomin Wan |
| author_facet | Guoguang Xiao Xiaoping Xie Juan Fan Jianjun Deng Shan Tan Yu Zhu Qin Guo Chaomin Wan |
| author_sort | Guoguang Xiao |
| collection | DOAJ |
| description | Background. There are no treatments with established efficacy for this disorder so far. Aim. To systematically review the efficacy of acotiamide in the treatment of patients with FD. Methods. We searched main electronic databases through November 2013. RCTs evaluating the efficacy of acotiamide versus placebo in FD patients were included. Pooled risk ratio (RR) with 95% confidential interval (CI) was calculated. Results. Six publications including seven RCTs were eligible for inclusion. The summary RR of overall improvement of FD symptoms in patients receiving acotiamide versus placebo was 1.29 (95% CI, 1.19–1.40, P<0.00001; I2=15%). Acotiamide improved the symptoms of patients with postprandial distress syndrome (PDS) (RR, 1.29; 95% CI, 1.09–1.53, P=0.003; I2=0%), and the summary RR for patients with epigastric pain syndrome (EPS) was 0.92 (95% CI, 0.76–1.11, P=0.39; I2=0%). Acotiamide showed a significantly beneficial effect on the elimination of some individual FD symptoms compared with placebo. Adverse events were not significantly different between acotiamide and placebo groups. Subgroup analyses suggested that acotiamide 100 mg three times daily (tid) showed consistent efficacy not only for the overall improvement but also for the elimination of some individual symptoms in FD patients. Conclusions. Acotiamide has the potential to improve the symptoms of patients with FD, particularly of patients with PDS, without major adverse effects. The dosage of acotiamide 100 mg tid might be the appropriate dose in the treatment of FD. |
| format | Article |
| id | doaj-art-1d81013e22734ba4bbb4d4993eb8d51f |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-1d81013e22734ba4bbb4d4993eb8d51f2025-08-20T02:01:39ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/541950541950Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-AnalysisGuoguang Xiao0Xiaoping Xie1Juan Fan2Jianjun Deng3Shan Tan4Yu Zhu5Qin Guo6Chaomin Wan7Department of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaDepartment of Pediatrics, The Medical Center of Dujiangyan, Chengdu 611830, ChinaDepartment of Pediatrics, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu 610072, ChinaDepartment of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaDepartment of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaDepartment of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaDepartment of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaDepartment of Pediatrics, West China Second Hospital, Sichuan University, No. 20, Section 3, Renmin Nanlu, Chengdu, Sichuan 610041, ChinaBackground. There are no treatments with established efficacy for this disorder so far. Aim. To systematically review the efficacy of acotiamide in the treatment of patients with FD. Methods. We searched main electronic databases through November 2013. RCTs evaluating the efficacy of acotiamide versus placebo in FD patients were included. Pooled risk ratio (RR) with 95% confidential interval (CI) was calculated. Results. Six publications including seven RCTs were eligible for inclusion. The summary RR of overall improvement of FD symptoms in patients receiving acotiamide versus placebo was 1.29 (95% CI, 1.19–1.40, P<0.00001; I2=15%). Acotiamide improved the symptoms of patients with postprandial distress syndrome (PDS) (RR, 1.29; 95% CI, 1.09–1.53, P=0.003; I2=0%), and the summary RR for patients with epigastric pain syndrome (EPS) was 0.92 (95% CI, 0.76–1.11, P=0.39; I2=0%). Acotiamide showed a significantly beneficial effect on the elimination of some individual FD symptoms compared with placebo. Adverse events were not significantly different between acotiamide and placebo groups. Subgroup analyses suggested that acotiamide 100 mg three times daily (tid) showed consistent efficacy not only for the overall improvement but also for the elimination of some individual symptoms in FD patients. Conclusions. Acotiamide has the potential to improve the symptoms of patients with FD, particularly of patients with PDS, without major adverse effects. The dosage of acotiamide 100 mg tid might be the appropriate dose in the treatment of FD.http://dx.doi.org/10.1155/2014/541950 |
| spellingShingle | Guoguang Xiao Xiaoping Xie Juan Fan Jianjun Deng Shan Tan Yu Zhu Qin Guo Chaomin Wan Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis The Scientific World Journal |
| title | Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis |
| title_full | Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis |
| title_short | Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis |
| title_sort | efficacy and safety of acotiamide for the treatment of functional dyspepsia systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2014/541950 |
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