The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge
Mycotoxins like aflatoxins (AFs), fumonisins (FBs), and ochratoxin A (OTA) pose serious health risks to humans and animals. Fruit pomace extracts, rich in natural nutrients and bioactive compounds, have the potential to enhance animal health and mitigate mycotoxin toxicity. This study evaluated a no...
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MDPI AG
2025-04-01
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| Series: | Toxins |
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| author | Sayantani Sihi Arora Anusuya Debnath Amrita Kumar Dhara Sudipto Haldar Raquel Codina Moreno Insaf Riahi |
| author_facet | Sayantani Sihi Arora Anusuya Debnath Amrita Kumar Dhara Sudipto Haldar Raquel Codina Moreno Insaf Riahi |
| author_sort | Sayantani Sihi Arora |
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| description | Mycotoxins like aflatoxins (AFs), fumonisins (FBs), and ochratoxin A (OTA) pose serious health risks to humans and animals. Fruit pomace extracts, rich in natural nutrients and bioactive compounds, have the potential to enhance animal health and mitigate mycotoxin toxicity. This study evaluated a novel liquid anti-mycotoxin solution (LAS), a combination of grape and olive pomace extract administered to broiler chickens through drinking water (2 L:1000 L) for 1–42 days under a natural multi-mycotoxin challenge. The 42-day trial with 288 one-day-old male Ross 308AP95 chicks included four experimental groups: a negative control (NC); NC+LAS; a positive control (PC) group fed a diet containing 80 μg/kg AFs, 1600 μg/kg FBs, and 50 μg/kg OTA; and PC+LAS. The growth performance, oxidative defense genes (liver), and stress biomarkers (blood) were analyzed. Mycotoxin exposure negatively affected body weight (BW), the feed conversion ratio (FCR), and the oxidative defense mechanism. LAS supplementation improved BW and the FCR, reduced Nrf-2 expression, and enhanced mycotoxin detoxification via lower EPHX1 expression. Though the LAS did not fully restore performance to NC levels, it significantly mitigated mycotoxin-induced damage. This study concluded that the LAS is a promising solution to improve broiler resilience against moderate to high mycotoxin exposure. |
| format | Article |
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| institution | OA Journals |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-04-01 |
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| series | Toxins |
| spelling | doaj-art-1d7f0fbcd2324d1593c4c562c7f509cc2025-08-20T01:56:45ZengMDPI AGToxins2072-66512025-04-0117521210.3390/toxins17050212The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin ChallengeSayantani Sihi Arora0Anusuya Debnath1Amrita Kumar Dhara2Sudipto Haldar3Raquel Codina Moreno4Insaf Riahi5Agrivet Research and Advisory Pvt Ltd., 714 Block A Lake Town, Kolkata 700089, IndiaDepartment of Biotechnology, Brainware University, 398 Ramkrishnapur Road, Barasat, North 24 Parganas, Kolkata 700125, IndiaAgrivet Research and Advisory Pvt Ltd., 714 Block A Lake Town, Kolkata 700089, IndiaAgrivet Research and Advisory Pvt Ltd., 714 Block A Lake Town, Kolkata 700089, IndiaBIŌNTE Nutrition S.L., Mexico St. 33, 43204 Reus, SpainBIŌNTE Nutrition S.L., Mexico St. 33, 43204 Reus, SpainMycotoxins like aflatoxins (AFs), fumonisins (FBs), and ochratoxin A (OTA) pose serious health risks to humans and animals. Fruit pomace extracts, rich in natural nutrients and bioactive compounds, have the potential to enhance animal health and mitigate mycotoxin toxicity. This study evaluated a novel liquid anti-mycotoxin solution (LAS), a combination of grape and olive pomace extract administered to broiler chickens through drinking water (2 L:1000 L) for 1–42 days under a natural multi-mycotoxin challenge. The 42-day trial with 288 one-day-old male Ross 308AP95 chicks included four experimental groups: a negative control (NC); NC+LAS; a positive control (PC) group fed a diet containing 80 μg/kg AFs, 1600 μg/kg FBs, and 50 μg/kg OTA; and PC+LAS. The growth performance, oxidative defense genes (liver), and stress biomarkers (blood) were analyzed. Mycotoxin exposure negatively affected body weight (BW), the feed conversion ratio (FCR), and the oxidative defense mechanism. LAS supplementation improved BW and the FCR, reduced Nrf-2 expression, and enhanced mycotoxin detoxification via lower EPHX1 expression. Though the LAS did not fully restore performance to NC levels, it significantly mitigated mycotoxin-induced damage. This study concluded that the LAS is a promising solution to improve broiler resilience against moderate to high mycotoxin exposure.https://www.mdpi.com/2072-6651/17/5/212mycotoxinliquid anti-mycotoxin solutionbroiler chicken |
| spellingShingle | Sayantani Sihi Arora Anusuya Debnath Amrita Kumar Dhara Sudipto Haldar Raquel Codina Moreno Insaf Riahi The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge Toxins mycotoxin liquid anti-mycotoxin solution broiler chicken |
| title | The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge |
| title_full | The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge |
| title_fullStr | The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge |
| title_full_unstemmed | The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge |
| title_short | The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge |
| title_sort | efficacy of a novel water soluble anti mycotoxin solution in improving broiler chicken performance under mycotoxin challenge |
| topic | mycotoxin liquid anti-mycotoxin solution broiler chicken |
| url | https://www.mdpi.com/2072-6651/17/5/212 |
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