Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening

Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening

Recently, there has been a co-evolution of mammalian libraries and diverse microfluidic approaches for therapeutic antibody hit discovery. Mammalian libraries enable the preservation of full immune repertoires, produce hit candidates in final format and facilitate broad combinatorial bispecific anti...

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Bibliographic Details
Main Authors: Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji, Achim Doerner
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Antibodies
display secretion switch
function first screen
mammalian libraries
microfluidics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2251190
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https://www.tandfonline.com/doi/10.1080/19420862.2023.2251190

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