Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways

Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways

Abstract Excessive exposure to ultraviolet B (UVB) radiation induces oxidative stress and inflammatory responses, accelerating the senescence process of skin cells. Vorinostat (SAHA), a histone deacetylase inhibitor (HDACi), is typically administered to patients with peripheral T-cell lymphoma, cuta...

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Bibliographic Details
Main Authors: Qianlong Dai, Zhiwei Wang, Xue Wang, Wei Lian, Yuchen Ge, Shujia Song, Fuxing Li, Bingxiang Zhao, Lihua Li, Xiaobo Wang, Min Zhou, Jianjie Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Vorinostat
UVB-induced
Anti-photoaging
mTOR
NF-κB
Online Access:https://doi.org/10.1038/s41598-025-95624-4
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