Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma
Neurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old boy with stage 4 mature high-grade B cell lymphoma who presented with a two-week history of right ulnar neu...
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| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1477848/full |
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| author | Evelyn Ruoyun Lu Evelyn Ruoyun Lu Wai Lan Yeung Jeffrey Ping Wa Yau King Sun Chu Elaine Yee Ling Kan Alan Kwok Shing Chiang Alan Kwok Shing Chiang |
| author_facet | Evelyn Ruoyun Lu Evelyn Ruoyun Lu Wai Lan Yeung Jeffrey Ping Wa Yau King Sun Chu Elaine Yee Ling Kan Alan Kwok Shing Chiang Alan Kwok Shing Chiang |
| author_sort | Evelyn Ruoyun Lu |
| collection | DOAJ |
| description | Neurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old boy with stage 4 mature high-grade B cell lymphoma who presented with a two-week history of right ulnar neuropathy and left sciatic neuropathy one month after the completion of frontline chemotherapy. This case report illustrates the rare presentation of NL in lymphoma relapse and hopes to emphasize how early identification of this diagnosis and timely treatment are essential. Moreover, this case points out how USG, in the context of palpable mass and localized neurological signs, could facilitate a diagnosis of NL. |
| format | Article |
| id | doaj-art-1d782c602e5d44baa5e1b01b7a6a6441 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-1d782c602e5d44baa5e1b01b7a6a64412025-08-20T03:51:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.14778481477848Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphomaEvelyn Ruoyun Lu0Evelyn Ruoyun Lu1Wai Lan Yeung2Jeffrey Ping Wa Yau3King Sun Chu4Elaine Yee Ling Kan5Alan Kwok Shing Chiang6Alan Kwok Shing Chiang7Department of Pediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Nuclear Medicine, Queen Elizabeth Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Radiology, Hong Kong Children’s Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaNeurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old boy with stage 4 mature high-grade B cell lymphoma who presented with a two-week history of right ulnar neuropathy and left sciatic neuropathy one month after the completion of frontline chemotherapy. This case report illustrates the rare presentation of NL in lymphoma relapse and hopes to emphasize how early identification of this diagnosis and timely treatment are essential. Moreover, this case points out how USG, in the context of palpable mass and localized neurological signs, could facilitate a diagnosis of NL.https://www.frontiersin.org/articles/10.3389/fonc.2025.1477848/fullneurolymphomatosisperipheral neuropathyhigh grade B cell lymphomaneuropathypediatric lymphoma |
| spellingShingle | Evelyn Ruoyun Lu Evelyn Ruoyun Lu Wai Lan Yeung Jeffrey Ping Wa Yau King Sun Chu Elaine Yee Ling Kan Alan Kwok Shing Chiang Alan Kwok Shing Chiang Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma Frontiers in Oncology neurolymphomatosis peripheral neuropathy high grade B cell lymphoma neuropathy pediatric lymphoma |
| title | Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma |
| title_full | Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma |
| title_fullStr | Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma |
| title_full_unstemmed | Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma |
| title_short | Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma |
| title_sort | case report neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high grade b cell lymphoma |
| topic | neurolymphomatosis peripheral neuropathy high grade B cell lymphoma neuropathy pediatric lymphoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1477848/full |
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