Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series
ABSTRACT Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and ARD using conventional and quantitative PCR and parasi...
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Sociedade Brasileira de Medicina Tropical (SBMT)
2025-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100802&lng=en&tlng=en |
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| author | Noemia Barbosa Carvalho Vera Lucia Teixeira de Freitas Nadia Emi Aikawa Lucas Teixeira Vieira Rita Cristina Bezerra Adriana Coraccini Tonácio de Proença Karina Bonfiglioli Érika Yoshie Shimoda Nakanishi Hermes Ryoiti Higashino Maria Aparecida Shikanai-Yasuda |
| author_facet | Noemia Barbosa Carvalho Vera Lucia Teixeira de Freitas Nadia Emi Aikawa Lucas Teixeira Vieira Rita Cristina Bezerra Adriana Coraccini Tonácio de Proença Karina Bonfiglioli Érika Yoshie Shimoda Nakanishi Hermes Ryoiti Higashino Maria Aparecida Shikanai-Yasuda |
| author_sort | Noemia Barbosa Carvalho |
| collection | DOAJ |
| description | ABSTRACT Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and ARD using conventional and quantitative PCR and parasitology. Five patients showed parasitemia; two had elevated levels of parEq/mL (49-458.7). One patient received benznidazole with a marked decrease in parasitemia; in the other, treatment was discontinued after 12 days due to toxicity. No CDR occurred. These findings support the need for qPCR standardization for preemptive therapy and suggest that benznidazole may prevent CDR in patients with high parasitemia. |
| format | Article |
| id | doaj-art-1d76bcea41f74f2bbf157f80b029241a |
| institution | DOAJ |
| issn | 1678-9849 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj-art-1d76bcea41f74f2bbf157f80b029241a2025-08-20T03:19:28ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492025-06-015810.1590/0037-8682-0419-2024Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case seriesNoemia Barbosa Carvalhohttps://orcid.org/0000-0002-1884-9526Vera Lucia Teixeira de Freitashttps://orcid.org/0000-0003-1112-081XNadia Emi Aikawahttps://orcid.org/0000-0002-7585-4348Lucas Teixeira Vieirahttps://orcid.org/0000-0002-3073-9477Rita Cristina Bezerrahttps://orcid.org/0009-0001-6162-9852Adriana Coraccini Tonácio de Proençahttps://orcid.org/0000-0002-1038-8796Karina Bonfigliolihttps://orcid.org/0000-0003-3547-5674Érika Yoshie Shimoda Nakanishihttps://orcid.org/0000-0002-6928-385XHermes Ryoiti Higashinohttps://orcid.org/0000-0002-2038-1539Maria Aparecida Shikanai-Yasudahttps://orcid.org/0000-0003-3864-041XABSTRACT Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and ARD using conventional and quantitative PCR and parasitology. Five patients showed parasitemia; two had elevated levels of parEq/mL (49-458.7). One patient received benznidazole with a marked decrease in parasitemia; in the other, treatment was discontinued after 12 days due to toxicity. No CDR occurred. These findings support the need for qPCR standardization for preemptive therapy and suggest that benznidazole may prevent CDR in patients with high parasitemia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100802&lng=en&tlng=enChagas diseaseAutoimmune rheumatic diseasesT. cruziParasitemiaqPCR |
| spellingShingle | Noemia Barbosa Carvalho Vera Lucia Teixeira de Freitas Nadia Emi Aikawa Lucas Teixeira Vieira Rita Cristina Bezerra Adriana Coraccini Tonácio de Proença Karina Bonfiglioli Érika Yoshie Shimoda Nakanishi Hermes Ryoiti Higashino Maria Aparecida Shikanai-Yasuda Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Autoimmune rheumatic diseases T. cruzi Parasitemia qPCR |
| title | Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series |
| title_full | Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series |
| title_fullStr | Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series |
| title_full_unstemmed | Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series |
| title_short | Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series |
| title_sort | quantitative pcr for parasitemia monitoring and preemptive therapy in patients with chagas disease and autoimmune rheumatic disorders undergoing biologic treatment a case series |
| topic | Chagas disease Autoimmune rheumatic diseases T. cruzi Parasitemia qPCR |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100802&lng=en&tlng=en |
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