Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium
Objectives. The habit of khat chewing is prevalent in many Middle Eastern and African cultures and has been associated with various adverse conditions in humans. This study aimed to describe histological changes induced by chronic khat chewing on the buccal mucosa. Methods. Biopsies of the buccal mu...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2015/104812 |
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| _version_ | 1832567919086665728 |
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| author | Ochiba Mohammed Lukandu Lionel Sang Koech Paul Ngugi Kiarie |
| author_facet | Ochiba Mohammed Lukandu Lionel Sang Koech Paul Ngugi Kiarie |
| author_sort | Ochiba Mohammed Lukandu |
| collection | DOAJ |
| description | Objectives. The habit of khat chewing is prevalent in many Middle Eastern and African cultures and has been associated with various adverse conditions in humans. This study aimed to describe histological changes induced by chronic khat chewing on the buccal mucosa. Methods. Biopsies of the buccal mucosa from 14 chronic khat chewers, 20 chronic khat chewers who also smoked tobacco, and 8 nonchewers were compared for epithelial thickness, degree and type of keratinization, and connective tissue changes. Results. Tissues from khat chewers depicted abnormal keratinization of the superficial cell layer and showed increased epithelial thickness affecting all layers. Epithelial thickness in control samples was 205 ± 26 μm whereas thickness in khat chewers and khat chewers who smoked tobacco was significantly higher measuring 330 ± 35 μm and 335 ± 19 μm, respectively. Tissues from khat chewers also showed increased intracellular edema, increased melanin pigment deposits, and increased number of rete pegs most of which were thin and deep. Conclusions. These results show that oral lesions induced by chronic chewing of khat in the buccal mucosa present with white and brown discoloration due to increased epithelial thickness, increased keratinization, and melanin deposition. |
| format | Article |
| id | doaj-art-1d756b5658dc424ebc8a59897657cb23 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-1d756b5658dc424ebc8a59897657cb232025-02-03T01:00:09ZengWileyInternational Journal of Dentistry1687-87281687-87362015-01-01201510.1155/2015/104812104812Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized EpitheliumOchiba Mohammed Lukandu0Lionel Sang Koech1Paul Ngugi Kiarie2Department of Maxillofacial Surgery, Oral Medicine, Pathology and Radiology, School of Dentistry, Moi University, P.O. Box 4606, Eldoret 30100, KenyaDepartment of Maxillofacial Surgery, Oral Medicine, Pathology and Radiology, School of Dentistry, Moi University, P.O. Box 4606, Eldoret 30100, KenyaDepartment of Oral Biology, Anatomy, Physiology and Biochemistry, School of Dentistry, Moi University, P.O. Box 4606, Eldoret 30100, KenyaObjectives. The habit of khat chewing is prevalent in many Middle Eastern and African cultures and has been associated with various adverse conditions in humans. This study aimed to describe histological changes induced by chronic khat chewing on the buccal mucosa. Methods. Biopsies of the buccal mucosa from 14 chronic khat chewers, 20 chronic khat chewers who also smoked tobacco, and 8 nonchewers were compared for epithelial thickness, degree and type of keratinization, and connective tissue changes. Results. Tissues from khat chewers depicted abnormal keratinization of the superficial cell layer and showed increased epithelial thickness affecting all layers. Epithelial thickness in control samples was 205 ± 26 μm whereas thickness in khat chewers and khat chewers who smoked tobacco was significantly higher measuring 330 ± 35 μm and 335 ± 19 μm, respectively. Tissues from khat chewers also showed increased intracellular edema, increased melanin pigment deposits, and increased number of rete pegs most of which were thin and deep. Conclusions. These results show that oral lesions induced by chronic chewing of khat in the buccal mucosa present with white and brown discoloration due to increased epithelial thickness, increased keratinization, and melanin deposition.http://dx.doi.org/10.1155/2015/104812 |
| spellingShingle | Ochiba Mohammed Lukandu Lionel Sang Koech Paul Ngugi Kiarie Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium International Journal of Dentistry |
| title | Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium |
| title_full | Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium |
| title_fullStr | Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium |
| title_full_unstemmed | Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium |
| title_short | Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium |
| title_sort | oral lesions induced by chronic khat use consist essentially of thickened hyperkeratinized epithelium |
| url | http://dx.doi.org/10.1155/2015/104812 |
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