Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease
Aim. To analyse the parameters of dental indices and the level of markers of infl ammation and oxidative stress in patients with chronic generalised periodontitis (CGP) with bronchiectatic disease and to develop a mathematical model for assessing the risk of CGP progression in patients with bronchie...
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2020-02-01
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| Series: | Кубанский научный медицинский вестник |
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| Online Access: | https://ksma.elpub.ru/jour/article/view/2074 |
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| author | Artem K. Sarkisov Vladimir A. Zelenskiy Ekaterina A. Polunina Karen A. Sarkisov |
| author_facet | Artem K. Sarkisov Vladimir A. Zelenskiy Ekaterina A. Polunina Karen A. Sarkisov |
| author_sort | Artem K. Sarkisov |
| collection | DOAJ |
| description | Aim. To analyse the parameters of dental indices and the level of markers of infl ammation and oxidative stress in patients with chronic generalised periodontitis (CGP) with bronchiectatic disease and to develop a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Materials and methods. A total of 70 patients with mild and moderate CGP were examined, which were divided into the following groups: patients with CGP without general somatic pathology (n = 33), and patients with CGP and bronchiectatic disease (n = 37). The control group consisted of somatically healthy individuals with intact periodontium (n = 40). Dental indices (PMA, PI, Muhlemann, OHI-s), infl ammatory markers (transforming growth factor beta 1 (TGFβ-1), lactoferrin (LF), interleukin-8 (IL-8), C — reactive protein (CRP)), and oxidative stress markers (malondialdehyde (MDA), as well as advanced oxidation protein products (AOPPs), and total superoxide dismutase (SOD)) were analysed in all patients included in the study. The method of binary logical regression was used to create a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Results. Dental indices and the level of markers of infl ammation and oxidative stress were statistically signifi cantly higher in all patients with CGP as compared to somatically healthy individuals, as well as in patients with CGP and bronchiectatic disease as compared to patients with CGP without general somatic pathology. Positive correlations of different strength between the studied markers of infl ammation and oxidative stress and dental indices were revealed. Based on the results of the correlation matrix data and using the binary logistic regression method, a mathematical model was developed that can be applied for assessing the risk of CGP progression in patients with bronchiectatic disease. The predictors of progression included in the mathematical model were: PI, TGFβ-1 and AOPPs. Conclusion. The data obtained indicate a greater severity of infl ammation and oxidative stress in CGP patients with comorbid pathology in the form of bronchiectatic disease and the infl uence of these processes on the periodontal condition. The proposed mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease is characterized by a high level of sensitivity and prognostic signifi cance, thus being applicable for use in clinical practice. |
| format | Article |
| id | doaj-art-1d71edb3faac4569a7cbf813184ff373 |
| institution | Kabale University |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| publishDate | 2020-02-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj-art-1d71edb3faac4569a7cbf813184ff3732025-08-20T03:57:12ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442020-02-01271728410.25207/1608-6228-2020-27-1-72-841163Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic diseaseArtem K. Sarkisov0Vladimir A. Zelenskiy1Ekaterina A. Polunina2Karen A. Sarkisov3Astrakhan State Medical UniversityStavropol State Medical UniversityAstrakhan State Medical UniversityAstrakhan State Medical UniversityAim. To analyse the parameters of dental indices and the level of markers of infl ammation and oxidative stress in patients with chronic generalised periodontitis (CGP) with bronchiectatic disease and to develop a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Materials and methods. A total of 70 patients with mild and moderate CGP were examined, which were divided into the following groups: patients with CGP without general somatic pathology (n = 33), and patients with CGP and bronchiectatic disease (n = 37). The control group consisted of somatically healthy individuals with intact periodontium (n = 40). Dental indices (PMA, PI, Muhlemann, OHI-s), infl ammatory markers (transforming growth factor beta 1 (TGFβ-1), lactoferrin (LF), interleukin-8 (IL-8), C — reactive protein (CRP)), and oxidative stress markers (malondialdehyde (MDA), as well as advanced oxidation protein products (AOPPs), and total superoxide dismutase (SOD)) were analysed in all patients included in the study. The method of binary logical regression was used to create a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Results. Dental indices and the level of markers of infl ammation and oxidative stress were statistically signifi cantly higher in all patients with CGP as compared to somatically healthy individuals, as well as in patients with CGP and bronchiectatic disease as compared to patients with CGP without general somatic pathology. Positive correlations of different strength between the studied markers of infl ammation and oxidative stress and dental indices were revealed. Based on the results of the correlation matrix data and using the binary logistic regression method, a mathematical model was developed that can be applied for assessing the risk of CGP progression in patients with bronchiectatic disease. The predictors of progression included in the mathematical model were: PI, TGFβ-1 and AOPPs. Conclusion. The data obtained indicate a greater severity of infl ammation and oxidative stress in CGP patients with comorbid pathology in the form of bronchiectatic disease and the infl uence of these processes on the periodontal condition. The proposed mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease is characterized by a high level of sensitivity and prognostic signifi cance, thus being applicable for use in clinical practice.https://ksma.elpub.ru/jour/article/view/2074chronic generalised periodontitisbronchiectatic diseasedental indicesinfl ammationoxidative stress |
| spellingShingle | Artem K. Sarkisov Vladimir A. Zelenskiy Ekaterina A. Polunina Karen A. Sarkisov Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease Кубанский научный медицинский вестник chronic generalised periodontitis bronchiectatic disease dental indices infl ammation oxidative stress |
| title | Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| title_full | Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| title_fullStr | Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| title_full_unstemmed | Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| title_short | Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| title_sort | prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease |
| topic | chronic generalised periodontitis bronchiectatic disease dental indices infl ammation oxidative stress |
| url | https://ksma.elpub.ru/jour/article/view/2074 |
| work_keys_str_mv | AT artemksarkisov prognosisofprogressionofchronicgeneralisedperiodontitisinpatientswithbronchiectaticdisease AT vladimirazelenskiy prognosisofprogressionofchronicgeneralisedperiodontitisinpatientswithbronchiectaticdisease AT ekaterinaapolunina prognosisofprogressionofchronicgeneralisedperiodontitisinpatientswithbronchiectaticdisease AT karenasarkisov prognosisofprogressionofchronicgeneralisedperiodontitisinpatientswithbronchiectaticdisease |