Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis
A 42-year-old woman was referred to an emergency department. She had an unresponsive corneal ulcer that was initially diagnosed as Herpes simplex virus keratitis. Later, the microbiological studies revealed fungal keratitis. Although the patient was given topical antifungal medication, the clinical...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Medical Mycology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753924000617 |
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| author | Mehrnaz Atighehchian Alireza Latifi Zohreh Nozarian Fahimeh Asadi Amoli Mehran Zarei-Ghanavati |
| author_facet | Mehrnaz Atighehchian Alireza Latifi Zohreh Nozarian Fahimeh Asadi Amoli Mehran Zarei-Ghanavati |
| author_sort | Mehrnaz Atighehchian |
| collection | DOAJ |
| description | A 42-year-old woman was referred to an emergency department. She had an unresponsive corneal ulcer that was initially diagnosed as Herpes simplex virus keratitis. Later, the microbiological studies revealed fungal keratitis. Although the patient was given topical antifungal medication, the clinical presentation did not support improvement. Despite using antifungal medication, the infiltration continued to progress, and the patient underwent therapeutic penetrating keratoplasty (T-PKP). Corneal tissue was collected and sent for histopathologic and molecular examination. The results revealed the presence of both Acanthamoeba T4 subgroup and Fusarium sp. This case emphasizes the importance of considering Acanthamoeba infection in progressive and non-responsive infectious keratitis, especially fungal specimens. Polymerase chain reaction (PCR) is an appropriate laboratory molecular diagnostic test for accurate diagnosis of Acanthamoeba keratitis. |
| format | Article |
| id | doaj-art-1d70860ecf6a42309bd1d7ade031d7fb |
| institution | DOAJ |
| issn | 2211-7539 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj-art-1d70860ecf6a42309bd1d7ade031d7fb2025-08-20T02:52:20ZengElsevierMedical Mycology Case Reports2211-75392025-03-014710068710.1016/j.mmcr.2024.100687Fungal keratitis complicating the diagnosis of Acanthamoeba keratitisMehrnaz Atighehchian0Alireza Latifi1Zohreh Nozarian2Fahimeh Asadi Amoli3Mehran Zarei-Ghanavati4Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranPathology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranPathology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranFarabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author.A 42-year-old woman was referred to an emergency department. She had an unresponsive corneal ulcer that was initially diagnosed as Herpes simplex virus keratitis. Later, the microbiological studies revealed fungal keratitis. Although the patient was given topical antifungal medication, the clinical presentation did not support improvement. Despite using antifungal medication, the infiltration continued to progress, and the patient underwent therapeutic penetrating keratoplasty (T-PKP). Corneal tissue was collected and sent for histopathologic and molecular examination. The results revealed the presence of both Acanthamoeba T4 subgroup and Fusarium sp. This case emphasizes the importance of considering Acanthamoeba infection in progressive and non-responsive infectious keratitis, especially fungal specimens. Polymerase chain reaction (PCR) is an appropriate laboratory molecular diagnostic test for accurate diagnosis of Acanthamoeba keratitis.http://www.sciencedirect.com/science/article/pii/S2211753924000617Fungal keratitisAcanthamoebaInfiltration |
| spellingShingle | Mehrnaz Atighehchian Alireza Latifi Zohreh Nozarian Fahimeh Asadi Amoli Mehran Zarei-Ghanavati Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis Medical Mycology Case Reports Fungal keratitis Acanthamoeba Infiltration |
| title | Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis |
| title_full | Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis |
| title_fullStr | Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis |
| title_full_unstemmed | Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis |
| title_short | Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis |
| title_sort | fungal keratitis complicating the diagnosis of acanthamoeba keratitis |
| topic | Fungal keratitis Acanthamoeba Infiltration |
| url | http://www.sciencedirect.com/science/article/pii/S2211753924000617 |
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