Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study
Abstract Background Few previous studies have addressed the impact of COVID-19 infection status on assisted reproductive technology outcomes. The purpose of this study was to assess whether COVID-19 infection affects ovulation induction outcomes and the laboratory outcomes of women undergoing assist...
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BMC
2025-02-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01601-w |
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| author | Yanhong Wu Shenghao Wu Weijue Su Junzhao Zhao Liangliang Ma |
| author_facet | Yanhong Wu Shenghao Wu Weijue Su Junzhao Zhao Liangliang Ma |
| author_sort | Yanhong Wu |
| collection | DOAJ |
| description | Abstract Background Few previous studies have addressed the impact of COVID-19 infection status on assisted reproductive technology outcomes. The purpose of this study was to assess whether COVID-19 infection affects ovulation induction outcomes and the laboratory outcomes of women undergoing assisted reproductive technology treatment. Methods In total, 363 patients were divided into three groups: the COVID-19 infection group (group A, n = 49), the COVID-19 recovery group (group B, n = 119) and the COVID-19 non-infection group (group C, n = 195). Intergroup comparisons of baseline characteristics, stimulation characteristics and laboratory outcomes were performed. Results The Gn dosage in group A was significantly higher than those in groups B and C. The duration of Gn treatment was longer in group A than in group B. In group B, the number of high-quality blastocysts was lower than that in group C. The rates of blastocyst formation (42.56%) and high-quality blastocyst formation (12.05%) in group B were significantly lower than those in group A (51.51%; P = 0.003, 16.58%; P = 0.026) and C (48.20%; P = 0.005, 16.49%; P = 0.002). The high-quality blastocyst rate in group C (34.20%) was the highest and was different from that in group B (28.33%). The main risk factor for high-quality blastocyst formation according to multivariate logistic regression analysis was recovery from COVID-19 (0.599, 95% CI: 0.360–0.996; P = 0.048). Conclusion Asymptomatic or mild COVID-19 infection prior to oocyte retrieval may not has a significant negative effect on ovulation induction outcomes or laboratory outcomes, although the number of Gn days and dose of Gn may increase. In addition, we should pay attention to infertile women recovering from COVID-19 infection and be aware of the significant reduction in the number of high-quality blastocysts in this population. |
| format | Article |
| id | doaj-art-1d6e5556884f42e5804c3b2bf72f5d56 |
| institution | Kabale University |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | Journal of Ovarian Research |
| spelling | doaj-art-1d6e5556884f42e5804c3b2bf72f5d562025-02-09T12:50:02ZengBMCJournal of Ovarian Research1757-22152025-02-011811910.1186/s13048-025-01601-wAsymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective studyYanhong Wu0Shenghao Wu1Weijue Su2Junzhao Zhao3Liangliang Ma4Department of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Vascular Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background Few previous studies have addressed the impact of COVID-19 infection status on assisted reproductive technology outcomes. The purpose of this study was to assess whether COVID-19 infection affects ovulation induction outcomes and the laboratory outcomes of women undergoing assisted reproductive technology treatment. Methods In total, 363 patients were divided into three groups: the COVID-19 infection group (group A, n = 49), the COVID-19 recovery group (group B, n = 119) and the COVID-19 non-infection group (group C, n = 195). Intergroup comparisons of baseline characteristics, stimulation characteristics and laboratory outcomes were performed. Results The Gn dosage in group A was significantly higher than those in groups B and C. The duration of Gn treatment was longer in group A than in group B. In group B, the number of high-quality blastocysts was lower than that in group C. The rates of blastocyst formation (42.56%) and high-quality blastocyst formation (12.05%) in group B were significantly lower than those in group A (51.51%; P = 0.003, 16.58%; P = 0.026) and C (48.20%; P = 0.005, 16.49%; P = 0.002). The high-quality blastocyst rate in group C (34.20%) was the highest and was different from that in group B (28.33%). The main risk factor for high-quality blastocyst formation according to multivariate logistic regression analysis was recovery from COVID-19 (0.599, 95% CI: 0.360–0.996; P = 0.048). Conclusion Asymptomatic or mild COVID-19 infection prior to oocyte retrieval may not has a significant negative effect on ovulation induction outcomes or laboratory outcomes, although the number of Gn days and dose of Gn may increase. In addition, we should pay attention to infertile women recovering from COVID-19 infection and be aware of the significant reduction in the number of high-quality blastocysts in this population.https://doi.org/10.1186/s13048-025-01601-wAssisted reproductive technologyCOVID-19High-quality blastocystOocyte retrievalOvulation induction |
| spellingShingle | Yanhong Wu Shenghao Wu Weijue Su Junzhao Zhao Liangliang Ma Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study Journal of Ovarian Research Assisted reproductive technology COVID-19 High-quality blastocyst Oocyte retrieval Ovulation induction |
| title | Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study |
| title_full | Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study |
| title_fullStr | Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study |
| title_full_unstemmed | Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study |
| title_short | Asymptomatic or mild COVID-19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes: a retrospective study |
| title_sort | asymptomatic or mild covid 19 infection in women prior to oocyte retrieval has no impact on embryo laboratory outcomes a retrospective study |
| topic | Assisted reproductive technology COVID-19 High-quality blastocyst Oocyte retrieval Ovulation induction |
| url | https://doi.org/10.1186/s13048-025-01601-w |
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